Bibliography

Sumiyoshi A, Shibata S, Lazarova D, Zhelev Z, Aoki I, Bakalova R. Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo. Redox Rep. 2023 Dec;28(1):2220531. doi: 10.1080/13510002.2023.2220531. PMID: 37581329; PMCID: PMC10435007.

Bakalova R, Lazarova D, Sumiyoshi A, Shibata S, Zhelev Z, Nikolova B, Semkova S, Vlaykova T, Aoki I, Higashi T. Redox-Cycling "Mitocans" as Effective New Developments in Anticancer Therapy. Int J Mol Sci. 2023 May 8;24(9):8435. doi:10.3390/ijms24098435. PMID: 37176145; PMCID: PMC10179378.

Ueno M, Shibata S, Nakanishi I, Aoki I, Yamada KI, Matsumoto KI. Effects of selenium deficiency on biological results of X-ray and carbon-ion beam irradiation in mice. J Clin Biochem Nutr. 2023 Mar;72(2):107-116. doi:10.3164/jcbn.22-57. Epub 2022 Dec 8. PMID: 36936873; PMCID: PMC10017320.

Ivanova D, Semkova S, Yaneva Z, Nicolova B, Zhelev Z, Bakalova R, Aoki I. Docosahexaenoic acid potentiates the anticancer effect of the menadione/ascorbate redox couple by increasing mitochondrial superoxide and accelerating ATP depletion. Anticancer Res. 2023 Mar;43(3):1213-1220.  doi: 10.21873/anticanres.16268.

Sugawara H, Furuta T, Sumiyoshi A, Iiyama M, Kamitani M, Suzuki A, Murakami A, Abe O, Aoki I, Akai H. Feasibility study of direct CT lymphangiography in mice: comparison with interstitial CT/MR lymphangiography. Eur Radiol. 2023 Jan 31. doi: 10.1007/s00330-023-09423-4. Epub ahead of print. PMID: 36719498.

Iki N, Nakane R, Masuya-Suzuki A, Ozawa Y, Maruoka T, Iiyama M, Sumiyoshi A, Aoki I. MRI Contrasting Agent Based on Mn-MOF-74 Nanoparticles with Coordinatively Unsaturated Sites. Mol Imaging Biol. 2023 Jan 18. doi:10.1007/s11307-023-01801-0. Epub ahead of print. PMID: 36653627.

Ueno M, Shibata S, Nakanishi I, Aoki I, Yamada K, Matsumoto KI. Effects of selenium deficiency on biological results of X-ray and carbon-ion beam irradiation in mice. Journal of Clinical Biochemistry and Nutrition. 2022 Dec. ID 22-57. doi: 10.3164/jcbn.22-57.

Ono M, Komatsu M, Ji B, Takado Y, Shimojo M, Minamihisamatsu T, Warabi E, Yanagawa T, Matsumoto G, Aoki I, Kanaan NM, Suhara T, Sahara N, Higuchi M. Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging Cell. 2022 Jul;21(7):e13615. doi: 10.1111/acel.13615. Epub 2022 Jun 5. PMID: 35662390; PMCID: PMC9282839.

Bakalova R, Aoki I, Zhelev Z, Higashi T. Corrigendum to "Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation" [Redox Biol. 53 (2022) 102337]. Redox Biol. 2022 Jul 8:102397. doi: 10.1016/j.redox.2022.102397. Epub ahead of print. Erratum for: Redox Biol. 2022 Jul;53:102337. PMID: 35817692. (Bakalova R, Aoki I, Zhelev Z, Higashi T. Cellular redox imbalance on the crossroad between mitochondrial dysfunction, senescence, and proliferation. Redox Biol. 2022 May 13;53:102337. doi: 10.1016/j.redox.2022.102337. Epub ahead of print. PMID: 35584568.)

Imaizumi A, Obata T, Kershaw J, Tachibana Y, Abe Y, Shibata S, Nitta N, Aoki I, Yasui M, Higashi T. Quantitative measurement of diffusion-weighted imaging signal using expression-controlled aquaporin-4 cells: Comparative study of 2-compartment and diffusion kurtosis imaging models. PLoS One. 2022 Apr 19;17(4):e0266465. doi: 10.1371/journal.pone.0266465. PMID: 35439261; PMCID: PMC9017930.

Utomo RY, Okada S, Sumiyoshi A, Aoki I, Nakamura H. Development of an MRI contrast agent for both detection and inhibition of the amyloid-β fibrillation process. RSC Adv. 2022 Feb 9;12(8):5027-5030. doi: 10.1039/d2ra00614f. PMID: 35425501; PMCID: PMC8981495.

Zhelev Z, Sumiyoshi A, Aoki I, Lazarova D, Vlaykova T, Higashi T, Bakalova R. Over-Reduced State of Mitochondria as a Trigger of "β-Oxidation Shuttle" in Cancer Cells. Cancers (Basel). 2022 Feb 10;14(4):871. doi:10.3390/cancers14040871. PMID: 35205619; PMCID: PMC8870273. Review. IF: 6.102.

Zhelev Z, Aoki I, Lazarova D, Vlaykova T, Higashi T, Bakalova R. A "Weird" Mitochondrial Fatty Acid Oxidation as a Metabolic "Secret" of Cancer. Oxid Med Cell Longev. 2022 Feb 8;2022:2339584. doi: 10.1155/2022/2339584. PMID: 35178152; PMCID: PMC8847026. Review. IF: 6.543.

Utomo RY, Okada S, Sumiyoshi A, Aoki I, Nakamura H. Development of an MRI contrast agent for both detection and inhibition of the amyloid-b fibrillation process. RSC Adv., 2022 12, 5027-5030.

Sumiyoshi A, Shibata S, Zhelev Z, Miller T, Lazarova D, Aoki I, Obata T, Higashi T, Bakalova R. Targeting Glioblastoma via Selective Alteration of Mitochondrial Redox State. Cancers (Basel). 2022 Jan 19;14(3):485. doi: 10.3390/cancers14030485. PMID: 35158753; PMCID: PMC8833725. IF: 6.102.

Ivanova D, Zhelev Z, Zlateva G, Lazarova D, Yaneva Z, Panovska R, Aoki I, Bakalova R. Effect of Alpha-tocopheryl Succinate on the Cytotoxicity of Anticancer Drugs Towards Leukemia Lymphocytes. Anticancer Res. 2022 Jan;42(1):547-554. doi: 10.21873/anticanres.15512. PMID: 34969764.

Takado Y, Takuwa H, Sampei K, Urushihata T, Takahashi M, Shimojo M, Uchida S, Nitta N, Shibata S, Nagashima K, Ochi Y, Ono M, Maeda J, Tomita Y, Sahara N, Near J, Aoki I, Shibata K, Higuchi M. MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice. J Cereb Blood Flow Metab. 2022 Jan;42(1):197-212. doi: 10.1177/0271678X211045449. Epub 2021 Sep 13. PMID: 34515548; PMCID: PMC8721779.

Matsumoto KI, Nakanishi I, Zhelev Z, Bakalova R, Aoki I. Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging. Antioxid Redox Signal. 2022 Jan;36(1-3):95-121. doi: 10.1089/ars.2021.0110. Epub 2021 Jul 28. PMID: 34148403. IF: 8.401.

Okada S, Takayasu S, Sumiyoshi A, Aoki I, Nakamura H. MRI-based glucose assay using magnetic nanoparticle sensors. Anal Sci. 2021 Dec 10;37(12):1765-1769. doi: 10.2116/analsci.21P082. Epub 2021 Jul 9. PMID: 34248090.

Sumiyoshi A, Shibata S, Zhelev Z, Miller T, Lazarova D, Zlateva G, Aoki I, Bakalova R. Pharmacological strategy for selective targeting of glioblastoma by redox-active combination drug - comparison with the chemotherapeutic standard-of-care temozolomide. Anticancer Res. 2021 Dec;41(12):6067-6076. doi:10.21873/anticanres.15426. PMID: 34848461.

Sato H, Takado Y, Toyoda S, Tsukamoto-Yasui M, Minatohara K, Takuwa H, Urushihata T, Takahashi M, Shimojo M, Ono M, Maeda J, Orihara A, Sahara N, Aoki I, Karakawa S, Isokawa M, Kawasaki N, Kawasaki M, Ueno S, Kanda M, Nishimura M, Suzuki K, Mitsui A, Nagao K, Kitamura A, Higuchi M. Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model. Sci Adv. 2021 Oct 22;7(43):eabd5046. doi:10.1126/sciadv.abd5046. Epub 2021 Oct 22. PMID: 34678069; PMCID: PMC8535828.

Hirabayashi T, Nagai Y, Hori Y, Inoue KI, Aoki I, Takada M, Suhara T, Higuchi M, Minamimoto T. Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network. Neuron. 2021 Oct 20;109(20):3312-3322.e5. doi: 10.1016/j.neuron.2021.08.032. PMID: 34672984.

Sawada K, Kamiya S, Aoki I. The proliferation of dentate gyrus progenitors in the ferret hippocampus by neonatal exposure to valproic acid. Front Neurosci. 2021 Sep 28;15:736313. doi: 10.3389/fnins.2021.736313.

Liu J, Cabral H, Song B, Aoki I, Chen Z, Nishiyama N, Huang Y, Kataoka K, Mi P. Nanoprobe-based magnetic resonance imaging of hypoxia predicts responses to radiotherapy, immunotherapy, and sensitizing treatments in pancreatic tumors. ACS Nano. 2021 Aug 6;15(8):13526-13538. doi: 10.1021/acsnano.1c04263. Epub ahead of print. PMID: 34355882. (IF = 15.881)

Yuba E, Takashima M, Hayashi T, Kokuryo D, Aoki I, Harada A, Aoshima S, Krishnan UM, Kono K. Multifunctional traceable liposomes with temperature-triggered drug release and neovasculature-targeting properties for improved cancer chemotherapy. Mol Pharm. 2021 Sep 6;18(9):3342-3351. doi: 10.1021/acs.molpharmaceut.1c00263. Epub 2021 Jul 29. PMID: 34324363. (IF = 4.939)

Abdul MA, Louis F, Aoki I, Lee SH, Chang YT, Matsusaki M. A near-infrared organic fluorescent probe for broad applications for blood vessels imaging by high-throughput screening via 3D-blood vessel models. Small Methods. 2021 June 16;5:2100338. doi: 10.1002/smtd.202100338. (IF = 14.188)

Sawada K, Kamiya S, Aoki I. Neonatal valproic acid exposure produces altered gyrification related to increased parvalbumin-immunopositive neuron density with thickened sulcal floors. PLoS One. 2021 Apr 20;16(4):e0250262. doi:10.1371/journal.pone.0250262. PMID: 33878144; PMCID: PMC8057614.

Okubo K, Takeda R, Murayama S, Umezawa M, Kamimura M, Osada K, Aoki I, Soga K. Size-controlled bimodal in vivo nanoprobes as near-infrared phosphors and positive contrast agents for magnetic resonance imaging. Sci Technol Adv Mater. 2021 Mar 10;22(1):160-172. doi: 10.1080/14686996.2021.1887712. (IF = 8.090)

Fairley LH, Sahara N, Aoki I, Ji B, Suhara T, Higuchi M, Barron AM. Neuroprotective effect of mitochondrial translocator protein ligand in a mouse model of tauopathy. J Neuroinflammation. 2021 Mar 19;18(1):76. doi:10.1186/s12974-021-02122-1. PMID: 33740987; PMCID: PMC7980620. (IF = 5.193)

Kimura A, Jo JI, Yoshida F, Hong Z, Tabata Y, Sumiyoshi A, Taguchi M, Aoki I. Ultra-small size gelatin nanogel as a blood brain barrier impermeable contrast agent for magnetic resonance imaging. Acta Biomater. 2021 Feb 15:S1742-7061(21)00102-1. doi: 10.1016/j.actbio.2021.02.016. Epub ahead of print. PMID: 33601066. (IF = 8.947)

Ji B, Ono M, Yamasaki T, Fujinaga M, Zhang MR, Seki C, Aoki I, Kito S, Sawada M, Suhara T, Sahara N, Higuchi M. Detection of Alzheimer's disease-related neuroinflammation by a PET ligand selective for glial versus vascular translocator protein. J Cereb Blood Flow Metab. 2021 Feb 8:271678X21992457. doi: 10.1177/0271678X21992457. Epub ahead of print. PMID: 33557690.

Lazarova D, Semkova S, Zlateva G, Higashi T, Aoki I, Bakalova R. Quantum Sensors to Track Total Redox-Status and Oxidative Stress in Cells and Tissues Using Electron-Paramagnetic Resonance, Magnetic Resonance Imaging, and Optical Imaging. Anal Chem. 2021 Feb 9;93(5):2828-2837. doi: 10.1021/acs.analchem.0c04116. Epub 2021 Jan 28. PMID: 33508934.

Nakatsuji H, Shioji Y, Hiraoka N, Okada Y, Kato N, Shibata S, Aoki I, Matsusaki M. Cancer-microenvironment triggered self-assembling therapy with molecular blocks. Mater Horiz. 2021, Feb 1, Advance Article. doi: 10.1039/D0MH02058C. (IF = 12.319)

Yamamoto S, Aoki I, Higashi T. Optical fiber-based ZnS(Ag) detector for selectively detecting alpha particles. Appl Radiat Isot. 2021 Mar;169:109495. doi: 10.1016/j.apradiso.2020.109495. Epub 2020 Dec 13. PMID: 33352477.

Setiawan H, Yuba E, Harada A, Aoki I, Kono K. Fabrication of gold nanohybrids modified with antibody and functional dendrimers for targeted photothermal theranostics. Nano Select. 2020 Dec 23;1-12. doi:10.1002/nano.202000218.

Bakalova R, Semkova S, Ivanova D, Zhelev Z, Miller T, Takeshima T, Shibata S, Lazarova D, Aoki I, Higashi T. Selective Targeting of Cancerous Mitochondria and Suppression of Tumor Growth Using Redox-Active Treatment Adjuvant. Oxid Med Cell Longev. 2020 Nov 2;2020:6212935. doi: 10.1155/2020/6212935. PMID: 33204397; PMCID: PMC7652615. (IF = 5.076)

Dimova J, Zlatareva D, Bakalova R, Aoki I, Hadjidekov G. Adnexal masses characterized on 3 tesla magnetic resonance imaging - added value of diffusion techniques. Radiol Oncol. 2020 Oct 21;54(4):419-428. doi:10.2478/raon-2020-0061. PMID: 33085642.

Tateishi K, Miyake Y, Kawazu M, Sasaki N, Nakamura T, Sasame J, Yoshii Y, Ueno T, Miyake A, Watanabe J, Matsushita Y, Shiba N, Udaka N, Ohki K, Fink AL, Tummala SS, Natsumeda M, Ikegaya N, Nishi M, Ohtake M, Miyazaki R, Suenaga J, Murata H, Aoki I, Miller JJ, Fujii Y, Ryo A, Yamanaka S, Mano H, Cahill DP, Wakimoto H, Chi AS, Batchelor TT, Nagane M, Ichimura K, Yamamoto T. A hyperactive RelA/p65-hexokinase 2 signaling axis drives primary central nervous system lymphoma. Cancer Res. 2020 Oct 16:canres.2425.2020. doi:10.1158/0008-5472.CAN-20-2425. Epub ahead of print. PMID: 33067267.

Nikolova B, Semkova S, Tsoneva I, Stoyanova E, Lefterov P, Lazarova D, Zhelev Z, Aoki I, Higashi T, Bakalova R. Redox-related Molecular Mechanism of Sensitizing Colon Cancer Cells to Camptothecin Analog SN38. Anticancer Res. 2020 Sep;40(9):5159-5170. doi: 10.21873/anticanres.14519. PMID: 32878804.

Arakawa H, Yamada H, Arai K, Kawanishi T, Nitta N, Shibata S, Matsumoto E, Yano K, Kato Y, Kumamoto T, Aoki I, Ogihara T. Possible utility of peptide-transporter-targeting [19F]dipeptides for visualization of the biodistribution of cancers by nuclear magnetic resonance imaging. Int J Pharm. 2020 Aug 30;586:119575. doi: 10.1016/j.ijpharm.2020.119575. Epub 2020 Jul 2. PMID: 32622809. (IF = 4.213)

Barron AM, Ji B, Fujinaga M, Zhang MR, Suhara T, Sahara N, Aoki I, Tsukada H, Higuchi M. In vivo positron emission tomography imaging of mitochondrial abnormalities in a mouse model of tauopathy. Neurobiol Aging. 2020 Oct;94:140-148. doi: 10.1016/j.neurobiolaging.2020.05.003. Epub 2020 May 19. PMID: 32623260.

Shimojo M, Takuwa H, Takado Y, Tokunaga M, Tsukamoto S, Minatohara K, Ono M, Seki C, Maeda J, Urushihata T, Minamihisamatsu T, Aoki I, Kawamura K, Zhang MR, Suhara T, Sahara N, Higuchi M. Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model. J Neurosci. 2020 Apr 22;40(17):3491-3501. doi:10.1523/JNEUROSCI.2880-19.2020. Epub 2020 Apr 7. PMID: 32265258; PMCID: PMC7178904.

Semkova S, Zhelev Z, Miller T, Sugaya K, Aoki I, Higashi T, Bakalova R. Menadione/Ascorbate Induces Overproduction of Mitochondrial Superoxide and Impairs Mitochondrial Function in Cancer: Comparative Study on Cancer and Normal Cells of the Same Origin. Anticancer Res. 2020 Apr;40(4):1963-1972. doi:10.21873/anticanres.14151. PubMed PMID: 32234885.

Bakalova R, Zhelev Z, Miller T, Aoki I, Higashi T. Vitamin C versus Cancer: Ascorbic Acid Radical and Impairment of Mitochondrial Respiration? Oxid Med Cell Longev. 2020 Jan 11;2020:1504048. doi: 10.1155/2020/1504048. PMID: 32411317; PMCID: PMC7201545. Review.  (IF = 5.076)

Sawada K, Kamiya S, Aoki I. Asymmetry of Cerebellar Lobular Development in Ferrets. Symmetry. 2020 May;12(5):735. doi:10.3390/sym12050735.

Qin C, Hou X, Khan T, Nitta N, Yanagawa M, Sakurai Y, Suzuki M, Masunaga SI, Tanaka H, Sakurai Y, Takahashi H, Aoki I, Yanagie H, Cabral H. Enhanced MRI-Guided Gadolinium(III) Neutron Capture Therapy by Polymeric Nanocarriers Promoting Tumor Accumulation and Intracellular Delivery. Chem Nano Mat. 2020 Mar;6:412-419. doi:10.1002/cnma.201900730. (IF = 3.384)

Tanimoto Y, Yamasaki T, Nagoshi N, Nishiyama Y, Nori S, Nishimura S, Iida T, Ozaki M, Tsuji O, Ji B, Aoki I, Jinzaki M, Matsumoto M, Fujibayashi Y, Zhang MR, Nakamura M, Okano H. In vivo monitoring of remnant undifferentiated neural cells following human iPS cell-derived neural stem/progenitor cells transplantation. Stem Cells Transl Med. 2020 Apr;9(4):465-477. doi:10.1002/sctm.19-0150. Epub 2020 Jan 6. PMID: 31904914; PMCID: PMC7103627.

Bakalova R, Zhelev Z, Miller T, Aoki I, Higashi T. New potential biomarker for stratification of patients for pharmacological vitamin C in adjuvant settings of cancer therapy. Redox Biol. 2020 Jan;28:101357. doi: 10.1016/j.redox.2019.101357. Epub 2019 Oct 23. Review. PubMed PMID: 31678721.

Grandjean J, Canella C, Anckaerts C, Ayrancı G, Bougacha S, Bienert T, Buehlmann D, Coletta L, Gallino D, Gass N, Garin CM, Nadkarni NA, Hübner NS, Karatas M, Komaki Y, Kreitz S, Mandino F, Mechling AE, Sato C, Sauer K, Shah D, Strobelt S, Takata N, Wank I, Wu T, Yahata N, Yeow LY, Yee Y, Aoki I, Chakravarty MM, Chang WT, Dhenain M, von Elverfeldt D, Harsan LA, Hess A, Jiang T, Keliris GA, Lerch JP, Meyer-Lindenberg A, Okano H, Rudin M, Sartorius A, Van der Linden A, Verhoye M, Weber-Fahr W, Wenderoth N, Zerbi V, Gozzi A. Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis. Neuroimage. 2019 Oct 12;205:116278. doi: 10.1016/j.neuroimage.2019.116278. [Epub ahead of print] PubMed PMID: 31614221.

Eguchi Y, Murayama S, Kanamoto H, Abe K, Miyagi M, Takahashi K, Ohtori S, Aoki I. Minimally invasive manganese-enhanced magnetic resonance imaging for the sciatic nerve tract tracing used intra-articularly administrated dextran–manganese encapsulated nanogels. JOR spine. 2019 June 6;2:e1059:1-8. doi:10.1002/jsp2.1059.

Nakamura M, Yamasaki T, Ueno M, Shibata S, Ozawa Y, Kamada T, Nakanishi I, Yamada KI, Aoki I, Matsumoto KI. Radiation-induced redox alteration in the mouse brain. Free Radic Biol Med. 2019 Aug 22;143:412-421. doi:10.1016/j.freeradbiomed.2019.08.020. PubMed PMID: 31446055.

Ivanova D, Zhelev Z, Semkova S, Aoki I, Bakalova R. Resveratrol Modulates the Redox-status and Cytotoxicity of Anticancer Drugs by Sensitizing Leukemic Lymphocytes and Protecting Normal Lymphocytes. Anticancer Res. 2019 Jul;39(7):3745-3755. doi: 10.21873/anticanres.13523. PubMed PMID: 31262901.

Lazarova D, Shibata S, Ishii I, Zlateva G, Zhelev Z, Aoki I, Higashi T, Bakalova R. Nitroxide-enhanced magnetic resonance imaging of kidney dysfunction in vivo based on redox-imbalance and oxidative stress. Gen Physiol Biophys. 2019 May;38(3):191-204. doi: 10.4149/gpb_2019001. PubMed PMID: 31184306.

Zhelev Z, Georgieva E, Lazarova D, Semkova S, Aoki I, Gulubova M, Higashi T, Bakalova R. "Redox Imaging" to Distinguish Cells with Different Proliferative Indexes: Superoxide, Hydroperoxides, and Their Ratio as Potential Biomarkers. Oxid Med Cell Longev. 2019 Apr 8;2019:6373685. doi: 10.1155/2019/6373685. eCollection 2019. PubMed PMID: 31089411; PubMed Central PMCID: PMC6476105. (IF=4.9)

Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma-Okumura T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H. Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. iScience. 2019 May 31;15:95-108. doi: 10.1016/j.isci.2019.04.007. Epub 2019 Apr 9. PubMed PMID: 31055217; PubMed Central PMCID: PMC6501120. (IF = 8.032)

Mimura K, Oga T, Sasaki T, Nakagaki K, Sato C, Sumida K, Hoshino K, Saito K, Miyawaki I, Suhara T, Aoki I, Minamimoto T, Ichinohe N. Abnormal axon guidance signals and reduced interhemispheric connection via anterior commissure in neonates of marmoset ASD model. Neuroimage. 2019 Jul 15;195:243-251. doi:10.1016/j.neuroimage.2019.04.006. Epub 2019 Apr 3. PubMed PMID: 30953832. (IF = 5.426)

Nonaka H, Nakanishi Y, Kuno S, Ota T, Mochidome K, Saito Y, Sugihara F, Takakusagi Y, Aoki I, Nagatoishi S, Tsumoto K, Sando S. Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction. Nat Commun. 2019 Feb 20;10(1):876. doi: 10.1038/s41467-019-08833-7. PubMed PMID:30787298; PubMed Central PMCID: PMC6382819. (IF: 12.353)

Shibata S, Shinozaki N, Suganami A, Ikegami S, Kinoshita Y, Hasegawa R, Kentaro H, Okamoto Y, Aoki I, Tamura Y, Iwadate Y. Photo-immune therapy with liposomally formulated phospholipid-conjugated indocyanine green induces specific antitumor responses with heat shock protein-70 expression in a glioblastoma model. Oncotarget. 2019 Jan 4;10(2):175-183. doi: 10.18632/oncotarget.26544. eCollection 2019 Jan 4. PubMed PMID: 30719212; PubMed Central PMCID: PMC6349435. (IF: 5.168)

Saito S, Sawada K, Aoki I. Prenatal Irradiation-Induced Hippocampal Abnormalities in Rats Evaluated Using Manganese-Enhanced MRI. Front Neural Circuits. 2018 Dec 17;12:112. doi: 10.3389/fncir.2018.00112. eCollection 2018. PubMed PMID: 30618648; PubMed Central PMCID: PMC6304475.

Sato C, Sawada K, Wright D, Higashi T, Aoki I. Isotropic 25-Micron 3D Neuroimaging Using ex vivo Microstructural Manganese-Enhanced MRI (MEMRI). Front Neural Circuits. 2018 Dec 6;12:110. doi: 10.3389/fncir.2018.00110. eCollection 2018. PubMed PMID: 30574072; PubMed Central PMCID: PMC6291442. (IF:3.131, HL:4.2)

Obata T, Kershaw J, Tachibana Y, Miyauchi T, Abe Y, Shibata S, Kawaguchi H, Ikoma Y, Takuwa H, Aoki I, Yasui M. Comparison of diffusion-weighted MRI and anti-Stokes Raman scattering (CARS) measurements of the inter-compartmental exchange-time of water in expression-controlled aquaporin-4 cells. Sci Rep. 2018 Dec 18;8(1):17954. doi: 10.1038/s41598-018-36264-9. PubMed PMID: 30560905; PubMed Central PMCID: PMC6298983.

Morishita K, Ueki S, Fuchi Y, Murayama S, Kaneko T, Narita N, Kobayashi S, Hirai G, Aoki I, Karasawa S. Self-Assembled Biradical Ureabenzene Nanoparticles for Magnetic Resonance Imaging. ACS Appl Nano Mater. 2018 Nov 26;1:6967-6975. doi: 10.1021/acsanm.8b01774. (IF: N/A)

Urushihata T, Takuwa H, Seki C, Tachibana Y, Takahashi M, Kershaw J, Takado Y, Aoki I, Higuchi M, Ito H, Obata T. Water Diffusion in the Brain of Chronic Hypoperfusion Model Mice: A Study Considering the Effect of Blood Flow. Magn Reson Med Sci. 2018 Oct 10;17(4):318-324. doi: 10.2463/mrms.mp.2017-0149. Epub 2018 Feb 13. PubMed PMID: 29434092. (IF: 1.141, HL: 6.0, 2016)

Araki T, Fuchi Y, Murayama S, Shiraishi R, Oyama T, Aso M, Aoki I, Kobayashi S, Yamada KI, Karasawa S. Fluorescence Tumor-Imaging Using a Thermo-Responsive Molecule with an Emissive Aminoquinoline Derivative. Nanomaterials (Basel). 2018 Oct 2;8(10). pii: E782. doi: 10.3390/nano8100782. PubMed PMID: 30279322. (IF: 3.504, 2017).

Nakakaji R, Umemura M, Mitsudo K, Kim JH, Hoshino Y, Sato I, Masuda T, Yamamoto M, Kioi M, Koizumi T, Fujita T, Yokoyama U, Iida M, Sato M, Sato H, Murofushi S, Shibata S, Aoki I, Eguchi H, Tohnai I, Ishikawa Y. Treatment of oral cancer using magnetized paclitaxel. Oncotarget. 2018 Feb 26;9(21):15591-15605. doi: 10.18632/oncotarget.24570. eCollection 2018 Mar 20. PubMed PMID: 29643995; PubMed Central PMCID: PMC5884650. (IF: 5.168)

Nitta N, Takakusagi Y, Kokuryo D, Shibata S, Tomita A, Higashi T, Aoki I, Harada M. Intratumoral evaluation of 3D microvasculature and nanoparticle distribution using a gadolinium-dendron modified nano-liposomal contrast agent with magnetic resonance micro-imaging. Nanomedicine. 2018 Apr 4;14(4):1315-1324. doi: 10.1016/j.nano.2018.03.006. [Epub ahead of print] PubMed PMID: 29626524.

Ivanova D, Zhelev Z, Getsov P, Nikolova B, Aoki I, Higashi T, Bakalova R. Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect. Redox Biol. 2018 Jun;16:352-358. doi:10.1016/j.redox.2018.03.013. Epub 2018 Mar 20. PubMed PMID: 29597144; PubMed Central PMCID: PMC5953218. (IF:7.126, HL:2.8)

Getsov P, Zhelev Z, Aoki I, Bakalova R. New Hypothesis and Alternative Approach for Imaging Neuronal Function and Metabolic Activity Based on Redox-Status. Balkan Med J. 2018 Mar 28. doi: 10.4274/balkanmedj.2018.0286. [Epub ahead of print] PubMed PMID: 29588266. (IF: 0.887, HL: 3.4)

Ivanova D, Zhelev Z, Lazarova D, Getsov P, Bakalova R, Aoki I. Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib. Anticancer Res. 2018 Mar;38(3):1407-1414. PubMed PMID: 29491065.

Ni R, Ji B, Ono M, Sahara N, Zhang MR, Aoki I, Nordberg A, Suhara T, Higuchi M. Comparative in-vitro and in-vivo quantifications of pathological tau deposits and their association with neurodegeneration in tauopathy mouse models. J Nucl Med. 2018 Jun;59(6):960-966. doi: 10.2967/jnumed.117.201632. Epub 2018 Feb 1. PubMed PMID: 29419480. (IF: 6.646, HL: 7.8, 2016)

Semkova S, Nikolova B, Zhelev Z, Tsoneva I, Zlateva G, Aoki I, Bakalova R. Loading Efficiency of Polymersomes with Contrast Agents and their Intracellular Delivery: Quantum Dots Versus Organic Dyes. Anticancer Res. 2018 Feb;38(2):825-831. PubMed PMID: 29374708. (IF: 1.937, HL: 7.2, 2016)

Sato K, Nitta N, Aoki I, Imai T, Shimokawa T. Repeated photon and C-ion irradiations in vivo have different impact on alteration of tumor characteristics. Sci Rep. 2018 Jan 23;8(1):1458. doi: 10.1038/s41598-018-19422-x. PubMed PMID: 29362374; PubMed Central PMCID: PMC5780469. (IF: 4.259, HL: 2.0, 2016)

Ishikawa A, Tokunaga M, Maeda J, Minamihisamatsu T, Shimojo M, Takuwa H, Ono M, Ni R, Hirano S, Kuwabara S, Ji B, Zhang MR, Aoki I, Suhara T, Higuchi M, Sahara N. In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510. J Alzheimers Dis. 2018;61(3):1037-1052. doi: 10.3233/JAD-170509. PubMed PMID: 29332041. (IF: 3.731, HL: 4.5, 2016)

Ogi H, Nitta N, Tando S, Fujimori A, Aoki I, Fushiki S, Itoh K. Longitudinal Diffusion Tensor Imaging Revealed Nerve Fiber Alterations in Aspm Mutated Microcephaly Model Mice. Neuroscience. 2018 Feb 10;371:325-336. doi:10.1016/j.neuroscience.2017.12.012. Epub 2017 Dec 16. PubMed PMID: 29253521. (IF: 3.277, HL: 9.2, 2016)

Jovtchev G, Stankov A, Georgieva A, Dobreva A, Bakalova R, Aoki I, Mileva M. Cytotoxic and genotoxic potential of Bulgarian Rosa alba L. essential oil – in vitro model study. Biotechnology & Biotechnological Equipment. 2018;32(2):513-519. doi:10.1080/13102818.2017.1423245 (IF: 1.227)

Sawada K, Aoki I. Biphasic aspect of sexually dimorphic ontogenetic trajectory of gyrification in the ferret cerebral cortex. Neuroscience. 2017 Nov 19;364:71-81. doi: 10.1016/j.neuroscience.2017.09.015. Epub 2017 Sep 19. PMID: 28935238.

Nakamura M, Shibata S, Yamasaki T, Ueno M, Nakanishi I, Matsumoto KI, Kamada T, Yamada KI, Aoki I. Feasibility of magnetic resonance redox imaging at low magnetic field: comparison at 1 T and 7 T. Am J Transl Res. 2017 Oct 15;9(10):4481-4491. eCollection 2017. PubMed PMID: 29118910; PubMed Central PMCID: PMC5666057. (IF: 2.829, HL: 2.5, 2016)

Bakalova R, Zhelev Z, Shibata S, Nikolova B, Aoki I, Higashi T. Impressive Suppression of Colon Cancer Growth by Triple Combination SN38/EF24/Melatonin: "Oncogenic" Versus "Onco-Suppressive" Reactive Oxygen Species. Anticancer Res. 2017 Oct;37(10):5449-5458. PubMed PMID: 28982855. (IF: 1.937, HL: 7.2, 2016)

Georgieva E, Ivanova D, Zhelev Z, Bakalova R, Gulubova M, Aoki I. Mitochondrial Dysfunction and Redox Imbalance as a Diagnostic Marker of "Free Radical Diseases". Anticancer Res. 2017 Oct;37(10):5373-5381. Review. PubMed PMID: 28982845. (IF: 1.937, HL: 7.2, 2016)

Morishita K, Okamoto Y, Murayama S, Usui K, Ohashi E, Hirai G, Aoki I, Karasawa S. Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes. Langmuir. 2017 Aug 8;33(31):7810-7817. doi:10.1021/acs.langmuir.7b01126. Epub 2017 Jul 24. PubMed PMID: 28678510. (IF: 3.833, HL: 8.1, 2016)

Luo Y, Fujita H, Nedelescu H, Biswas MS, Sato C, Ying S, Takahashi M, Akita K, Higashi T, Aoki I, Sugihara I. Lobular homology in cerebellar hemispheres of humans, non-human primates and rodents: a structural, axonal tracing and molecular expression analysis. Brain Struct Funct. 2017 Aug;222(6):2449-2472. doi: 10.1007/s00429-017-1436-9. Epub 2017 May 15. Review. PubMed PMID: 28508291. (IF: 4.698, HL: 3.2, 2016)

Sato K, Kerever A, Kamagata K, Tsuruta K, Irie R, Tagawa K, Okazawa H, Arikawa-Hirasawa E, Nitta N, Aoki I, Aoki S. Understanding microstructure of the brain by comparison of neurite orientation dispersion and density imaging (NODDI) with transparent mouse brain. Acta Radiol Open. 2017 Apr 17;6(4):2058460117703816. doi: 10.1177/2058460117703816. eCollection 2017 Apr. PubMed PMID: 28491462; PubMed Central PMCID: PMC5405886. (IF: 2.011, HL: 8.0, 2016)

Kokuryo D, Aoki I, Yuba E, Kono K, Aoshima S, Kershaw J, Saga T. Evaluation of a combination tumor treatment using thermo-triggered liposomal drug delivery and carbon ion irradiation. Transl Res. 2017 Jul;185:24-33. doi:10.1016/j.trsl.2017.04.001. Epub 2017 Apr 21. PubMed PMID: 28482173. (IF: 4.652, HL: 3.6, 2016)

Wells JA, Thomas DL, Saga T, Kershaw J, Aoki I. MRI of cerebral micro-vascular flow patterns: A multi-direction diffusion-weighted ASL approach. J Cereb Blood Flow Metab. 2017 Jun;37(6):2076-2083. doi: 10.1177/0271678X16660985. Epub 2016 Jan 1. PubMed PMID: 27461904.

Shiraishi K, Wang Z, Kokuryo D, Aoki I, Yokoyama M. A polymeric micelle magnetic resonance imaging (MRI) contrast agent reveals blood-brain barrier (BBB) permeability for macromolecules in cerebral ischemia-reperfusion injury. J Control Release. 2017 May 10;253:165-171. doi: 10.1016/j.jconrel.2017.03.020. Epub 2017 Mar 18. PubMed PMID: 28322975. (IF: 7.786, HL: 6.7, 2016)

Kim J-H, Eguchi H, Umemura M, Sato I, Yamada S, Hoshino Y, Masuda T, Aoki I, Sakurai K, Yamamoto M, and Ishikawa Y. Magnetic metal complex-conducting copolymer core-shell nanoassemblies for single-drug anticancer platform, NPG Asia Materials. 2017 9;e367. Doi: 10.1038/am.2017.29. (IF: 9.157, HL: 3.0, 2016)

Bakalova R, Lazarova D, Zlateva G, Zhelev Z, Spassov L, Aoki I. Visualization of overproduction of superoxide in living cells using nitroxide-enhanced magnetic resonance imaging – new insight on the molecular nature of the functional MRI, Annals of Sofia University “St. Kliment Ohridski” Faculty of Medicine, 2017 01;2:123-134 (IF: 0, HL: 0, 2016)

Sawada K, Aoki I. Age-dependent sexually-dimorphic asymmetric development of the ferret cerebellar cortex. Symmetry. 2017 Mar;9(40). doi: 10.3390/sym9030040.

Araki T, Murayama S, Usui K, Shimada T, Aoki I, Karasawa S. Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue. Nano Lett. 2017 Apr 12;17(4):2397-2403. doi:10.1021/acs.nanolett.6b05371. Epub 2017 Mar 7. PubMed PMID: 28264561.

Ohtake M, Umemura M, Sato I, Akimoto T, Oda K, Nagasako A, Kim JH, Fujita T, Yokoyama U, Nakayama T, Hoshino Y, Ishiba M, Tokura S, Hara M, Muramoto T, Yamada S, Masuda T, Aoki I, Takemura Y, Murata H, Eguchi H, Kawahara N, Ishikawa Y. Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment. Sci Rep. 2017 Feb 20;7:42783. doi: 10.1038/srep42783. PubMed PMID: 28218292; PubMed Central PMCID: PMC5316938.

Sawada K, Fukunishi K, Kashima M, Imai N, Saito S, Aoki I, Fukui Y. Regional difference in sulcal infolding progression correlated with cerebral cortical expansion in cynomolgus monkey fetuses. Congenit Anom (Kyoto). 2017 Jan 21. doi:10.1111/cga.12209. [Epub ahead of print] PubMed PMID: 28109019. (IF: 0.985)

Wells JA, Shibata S, Fujikawa A, Takahashi M, Saga T, Aoki I. Functional MRI of the Reserpine-Induced Putative Rat Model of Fibromyalgia Reveals Discriminatory Patterns of Functional Augmentation to Acute Nociceptive Stimuli. Sci Rep. 2017 Jan 12;7:38325. doi: 10.1038/srep38325. PubMed PMID: 28079057;PubMed Central PMCID: PMC5228122. (IF: 5.228)

Zhelev Z, Ivanova D, Bakalova R, Aoki I, Higashi T. Synergistic Cytotoxicity of Melatonin and New-generation Anticancer Drugs Against Leukemia Lymphocytes But Not Normal Lymphocytes. Anticancer Res. 2017 Jan;37(1):149-159. PubMed PMID: 28011485.

Nagai Y, Kikuchi E, Lerchner W, Inoue KI, Ji B, Eldridge MA, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang MR, Aoki I, Suhara T, Higuchi M, Takada M, Richmond BJ, Minamimoto T. PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. Nat Commun. 2016 Dec 6;7:13605. doi:10.1038/ncomms13605. PubMed PMID: 27922009; PubMed Central PMCID: PMC5150653. (IF: 12.124)

Ji B, Kaneko H, Minamimoto T, Inoue H, Takeuchi H, Kumata K, Zhang MR, Aoki I, Seki C, Ono M, Tokunaga M, Tsukamoto S, Tanabe K, Shin RM, Minamihisamatsu T, Kito S, Richmond BJ, Suhara T, Higuchi M. Multimodal Imaging for DREADD-Expressing Neurons in Living Brain and Their Application to Implantation of iPSC-Derived Neural Progenitors. J Neurosci. 2016 Nov 9;36(45):11544-11558. PubMed PMID: 27911758.

Georgieva E, Zhelev Z, Aoki I, Bakalova R, Higashi T. Detection of Redox Imbalance in Normal Lymphocytes with Induced Mitochondrial Dysfunction - EPR Study. Anticancer Res. 2016 Oct;36(10):5273-5279. PubMed PMID: 27798888.

Zhelev Z, Ivanova D, Bakalova R, Aoki I, Higashi T. Inhibition of the Pentose-phosphate Pathway Selectively Sensitizes Leukemia Lymphocytes to Chemotherapeutics by ROS-independent Mechanism. Anticancer Res. 2016 Nov;36(11):6011-6020. PubMed PMID: 27793928.

Ivanova D, Zhelev Z, Aoki I, Bakalova R, Higashi T. Overproduction of reactive oxygen species - obligatory or not for induction of apoptosis by anticancer drugs. Chin J Cancer Res. 2016 Aug;28(4):383-96. doi: 10.21147/j.issn.1000-9604.2016.04.01. PubMed PMID: 27647966; PubMed Central PMCID: PMC5018533.

Atanasova S, Nikolova B, Murayama S, Stoyanova E, Tsoneva I, Zhelev Z, Aoki I, Bakalova R. Electroinduced Delivery of Hydrogel Nanoparticles in Colon 26 Cells, Visualized by Confocal Fluorescence System. Anticancer Res. 2016 Sep;36(9):4601-6. PubMed PMID: 27630301.

Morishita K, Murayama S, Araki T, Aoki I, Karasawa S. Thermal- and pH-Dependent Size Variable Radical Nanoparticles and Its Water Proton Relaxivity for Metal-Free MRI Functional Contrast Agents. J Org Chem. 2016 Sep 16;81(18):8351-62. doi: 10.1021/acs.joc.6b01509. PubMed PMID: 27541011.

Mi P, Kokuryo D, Cabral H, Wu H, Terada Y, Saga T, Aoki I, Nishiyama N, Kataoka K. A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy. Nat Nanotechnol. 2016 Aug;11(8):724-30. doi: 10.1038/nnano.2016.72. Epub 2016 May 16. PubMed PMID: 27183055. (IF: 38.986, 2016-2017)

Nishino A, Tajima Y, Takuwa H, Masamoto K, Taniguchi J, Wakizaka H, Kokuryo D, Urushihata T, Aoki I, Kanno I, Tomita Y, Suzuki N, Ikoma Y, Ito H. Long-term effects of cerebral hypoperfusion on neural density and function using misery perfusion animal model. Sci Rep. 2016 Apr 27;6:25072. doi: 10.1038/srep25072. PubMed PMID: 27116932; PubMed Central PMCID: PMC4846861.

Zhelev Z, Ivanova D, Lazarova D, Aoki I, Bakalova R, Saga T. Docosahexaenoic Acid Sensitizes Leukemia Lymphocytes to Barasertib and Everolimus by ROS-dependent Mechanism Without Affecting the Level of ROS and Viability of Normal Lymphocytes. Anticancer Res. 2016 Apr;36(4):1673-82. PubMed PMID:27069145.

Bakalova R, Nikolova B, Murayama S, Atanasova S, Zhelev Z, Aoki I, Kato M, Tsoneva I, Saga T. Passive and electro-assisted delivery of hydrogel nanoparticles in solid tumors, visualized by optical and magnetic resonance imaging in vivo. Anal Bioanal Chem. 2016 Jan;408(3):905-14. doi:10.1007/s00216-015-9182-4. Epub 2015 Dec 29. PubMed PMID: 26715253.

Zhelev Z, Ivanova D, Aoki I, Saga T, Bakalova R. 2-Deoxy-D-glucose Sensitizes Cancer Cells to Barasertib and Everolimus by ROS-independent Mechanism(s). Anticancer Res. 2015 Dec;35(12):6623-32. PubMed PMID: 26637878.

Murayama S, Jo J, Arai K, Nishikido F, Bakalova R, Yamaya T, Saga T, Kato M, Aoki I. γ-PARCEL: Control of Molecular Release Using γ-Rays. Anal Chem. 2015 Dec 1;87(23):11625-9. doi: 10.1021/acs.analchem.5b03030. Epub 2015 Nov 16. PubMed PMID: 26525641.

Suganami A, Iwadate Y, Shibata S, Yamashita M, Tanaka T, Shinozaki N, Aoki I, Saeki N, Shirasawa H, Okamoto Y, Tamura Y. Liposomally formulated phospholipid-conjugated indocyanine green for intra-operative brain tumor detection and resection. Int J Pharm. 2015 Dec 30;496(2):401-6. doi:10.1016/j.ijpharm.2015.10.001. Epub 2015 Oct 23. PubMed PMID: 26453781.

Matsumoto KI, Yamasaki T, Nakamura M, Ishikawa J, Ueno M, Nakanishi I, Sekita A, Ozawa Y, Kamada T, Aoki I, Yamada KI. Brain contrasting ability of blood-brain-barrier-permeable nitroxyl contrast agents for magnetic resonance redox imaging. Magn Reson Med. 2015 Sep 28. doi: 10.1002/mrm.25918. [Epub ahead of print] PubMed PMID: 26414669.

Miura Y, Tsuji A, Sugyo A, Sudo H, Aoki I, Inubushi, M, Yashiro M, Hirakawa K, Cabral H, Nishiyama N, Saga T, Kataoka K. Polymeric Micelle Platform for Multimodal Tomographic Imaging to Detect Scirrhous Gastric Cancer. ACS Biomater Sci Eng, 2015, 1 (11):1067-76. doi: 10.1021/acsbiomaterials.5b00142.

Bakalova R, Georgieva E, Ivanova D, Zhelev Z, Aoki I, Saga T. Magnetic resonance imaging of mitochondrial dysfunction and metabolic activity, accompanied by overproduction of superoxide. ACS Chem Neurosci. 2015 Dec 16;6(12):1922-9. doi: 10.1021/acschemneuro.5b00220. Epub 2015 Sep 28. PubMed PMID: 26367059.

Okada M, Kikuchi T, Okamura T, Ikoma Y, Tsuji AB, Wakizaka H, Kamakura T, Aoki I, Zhang MR, Kato K. In-vivo imaging of blood-brain barrier permeability using positron emission tomography with 2-amino-[3-11C]isobutyric acid. Nucl Med Commun. 2015 Dec;36(12):1239-48. doi: 10.1097/MNM.0000000000000385. PubMed PMID: 26397998.

Aoki I,* Yoneyama M, Hirose J, Minemoto Y, Koyama T, Kokuryo D, Bakalova R, Murayama S, Saga T, Aoshima S, Ishizaka Y, Kono K. Thermoactivatable polymer-grafted liposomes for low-invasive image-guided chemotherapy. Transl Res. 2015 Dec;166(6):660-673.e1. doi: 10.1016/j.trsl.2015.07.009. Epub 2015 Aug 6. PubMed PMID: 26303887.

Bakalova R, Zhelev Z, Nikolova B, Murayama S, Lazarova D, Tsoneva I, Aoki I. Lymph node mapping using quantum dot-labeled polymersomes. Gen Physiol Biophys. 2015 Oct;34(4):393-8. PubMed PMID: 26221745.

Nikolova B, Atanasova S, Mudrov T, Tsoneva I, Zhelev Z, Bakalova R, Aoki I. Image-guided Electro-assisted Drug Delivery, International Journal Bioautomation. 2015 19(2):259-266. ISSN:1314-1902.

Sawada K, Horiuchi-Hirose M, Saito S, Aoki I. Male prevalent enhancement of leftward asymmetric development of the cerebellar cortex in ferrets (Mustela putorius). Laterality. 2015 Nov;20(6):723-37. doi: 10.1080/1357650X.2015.1047379. Epub 2015 Jun 23. PubMed PMID: 26102223.

Mi P, Dewi N, Yanagie H, Kokuryo D, Suzuki M, Sakurai Y, Li Y, Aoki I, Ono K, Takahashi H, Cabral H, Nishiyama N, Kataoka K. Hybrid Calcium Phosphate-Polymeric Micelles Incorporating Gadolinium Chelates for Imaging-Guided Gadolinium Neutron Capture Tumor Therapy. ACS Nano. 2015 Jun 23;9(6):5913-21. doi:10.1021/acsnano.5b00532. Epub 2015 Jun 11. PubMed PMID: 26033034.

Bakalova R, Lazarova D, Nikolova B, Atanasova S, Zlateva G, Zhelev Z, Aoki I. Delivery of size-controlled long-circulating polymersomes in solid tumors, visualized by quantum dots and optical imaging in vivo. Biotechnol Biotechnol Equip. 2015 Jan 2;29(1):175-180. Epub 2014 Nov 26. PubMed PMID: 26019630; PubMed Central PMCID: PMC4434099.

Sawada K, Horiuchi-Hirose M, Saito S, Aoki I. Sexual dimorphism of sulcal morphology of the ferret cerebrum revealed by MRI-based sulcal surface morphometry. Front Neuroanat. 2015 May 6;9:55. doi: 10.3389/fnana.2015.00055. eCollection 2015. PubMed PMID: 25999821; PubMed Central PMCID: PMC4422084.

Kawamura W, Miura Y, Kokuryo D, Toh K, Yamada N, Nomoto T, Matsumoto Y, Aoki I, Kano MR, Nishiyama N, Saga T, Kishimura A, Kataoka K*. Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas. Sci Technol Adv Mater. 2015 June;16(3) 035004:1-13. doi:10.1088/1468-6996/16/3/035004

Eguchi H, Umemura M, Kurotani R, Fukumura H, Sato I, Kim JH, Hoshino Y, Lee J, Amemiya N, Sato M, Hirata K, Singh DJ, Masuda T, Yamamoto M, Urano T, Yoshida K, Tanigaki K, Yamamoto M, Sato M, Inoue S, Aoki I, Ishikawa Y. A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging. Sci Rep. 2015 Mar 17;5:9194. doi: 10.1038/srep09194. PubMed PMID: 25779357; PubMed Central PMCID: PMC4361848.

Hasegawa S, Morokoshi Y, Tsuji AB, Kokubo T, Aoki I, Furukawa T, Zhang MR, Saga T. Quantifying initial cellular events of mouse radiation lymphomagenesis and its tumor prevention in vivo by positron emission tomography and magnetic resonance imaging. Mol Oncol. 2015 Mar;9(3):740-8. doi:10.1016/j.molonc.2014.11.009. Epub 2014 Dec 3. PubMed PMID: 25510653.

Gündüz S, Nitta N, Vibhute S, Shibata S, Mayer ME, Logothetis NK, Aoki I, Angelovski G. Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion. Chem Commun (Camb). 2015 Feb 18;51(14):2782-5. doi:10.1039/c4cc07540d. PubMed PMID: 25383973. (IF: 6.567)

Kokuryo D, Nakashima S, Ozaki F, Yuba E, Chuang KH, Aoshima S, Ishizaka Y, Saga T, Kono K, Aoki I. Evaluation of Thermo-triggered Drug Release in Intramuscular-transplanted Tumors using Thermosensitive Polymer-modified Liposomes and MRI. Nanomedicine. 2015 Jan;11(1):229-38. doi: 10.1016/j.nano.2014.09.001. Epub 2014 Sep 16. PubMed PMID: 25229542.

Tajima Y, Takuwa H, Kokuryo D, Kawaguchi H, Seki C, Masamoto K, Ikoma Y, Taniguchi J, Aoki I, Tomita Y, Suzuki N, Kanno I, Saeki N, Ito H. Changes in cortical microvasculature during misery perfusion measured by two-photon laser scanning microscopy. J Cereb Blood Flow Metab. 2014 Aug;34(8):1363-72. doi: 10.1038/jcbfm.2014.91. Epub 2014 May 21. PubMed PMID: 24849667; PubMed Central PMCID: PMC4126097.

Bennett KM, Jo JI, Cabral H, Bakalova R, Aoki I. MR imaging techniques for nano-pathophysiology and theranostics. Adv Drug Deliv Rev. 2014 Jul 30;74C:75-94. doi: 10.1016/j.addr.2014.04.007. Epub 2014 Apr 27. Review. PubMed PMID: 24787226.

Kuroiwa D, Obata T, Kawaguchi H, Autio J, Hirano M, Aoki I, Kanno I, Kershaw J. Signal contributions to heavily diffusion-weighted functional magnetic resonance imaging investigated with multi-SE-EPI acquisitions. Neuroimage. 2014 Sep;98:258-65. doi: 10.1016/j.neuroimage.2014.04.050. Epub 2014 Apr 26. PubMed PMID: 24780698.

Sasaki N, Jo J, Aoki I, Sato K. Magnetic resonance imaging of a microvascular-interstitium model on a microfluidic device. Anal Biochem. 2014 Aug 1;458:72-4. doi: 10.1016/j.ab.2014.03.020. Epub 2014 Apr 5. PubMed PMID: 24708939.

Tanaka H, Yamaguchi S, Jo J, Aoki I, Tabata Y, Takahashi T. Synthesis of a dextran-based bone tracer for in vivo magnetic resonance and optical imaging by two orthogonal coupling reactions. RSC Adv. 2014 Apr;4:7561-5. doi: 10.1039/c3ra46142d.

Hattori S, Hagihara H, Ohira K, Aoki I, Saga T, Suhara T, Higuchi M, Miyakawa T. In vivo evaluation of cellular activity in αCaMKII heterozygous knockout mice using manganese-enhanced magnetic resonance imaging (MEMRI). Front Integr Neurosci. 2013 Nov 11;7:76. doi: 10.3389/fnint.2013.00076. eCollection 2013. PubMed PMID: 24273499; PubMed Central PMCID: PMC3822296.

Takanashi J, Nitta N, Iwasaki N, Saito S, Tanaka R, Barkovich AJ, Aoki I. Neurochemistry in shiverer mouse depicted on MR spectroscopy. J Magn Reson Imaging. 2014 Jun;39(6):1550-7. doi: 10.1002/jmri.24306. Epub 2013 Nov 14. PubMed PMID: 24243812.

Mi P, Kokuryo D, Cabral H, Kumagai M, Nomoto T, Aoki I, Terada Y, Kishimura A, Nishiyama N, Kataoka K. Hydrothermally synthesized PEGylated calcium phosphate nanoparticles incorporating Gd-DTPA for contrast enhanced MRI diagnosis of solid tumors. J Control Release. 2014 Jan 28;174:63-71. doi: 10.1016/j.jconrel.2013.10.038. Epub 2013 Nov 6. PubMed PMID: 24211705.

Murayama S, Jo JI, Shibata Y, Liang K, Santa T, Saga T, Aoki I, Kato M. The Simple Preparation of Polyethylene Glycol-Based Soft Nanoparticles Containing Dual Imaging Probes. J. Mater. Chem. B. 2013;1:4932-8. doi:10.1039/C3TB20828A.

Takuwa H, Tajima Y, Kokuryo D, Matsuura T, Kawaguchi H, Masamoto K, Taniguchi J, Ikoma Y, Seki C, Aoki I, Tomita Y, Suzuki N, Kanno I, Ito H. Hemodynamic changes during neural deactivation in awake mice: a measurement by laser-Doppler flowmetry in crossed cerebellar diaschisis. Brain Res. 2013 Nov 6;1537:350-5. doi: 10.1016/j.brainres.2013.09.023. Epub 2013 Sep 25. PubMed PMID: 24076448.

Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. 2013 Sep 18;79(6):1094-108. doi: 10.1016/j.neuron.2013.07.037. PubMed PMID: 24050400; PubMed Central PMCID: PMC3809845.

Zhelev Z, Bakalova R, Aoki I, Lazarova D, Saga T. Imaging of superoxide generation in the dopaminergic area of the brain in Parkinson's disease, using mito-TEMPO. ACS Chem Neurosci. 2013 Nov 20;4(11):1439-45. doi: 10.1021/cn400159h. Epub 2013 Sep 16. PubMed PMID: 24024751; PubMed Central PMCID: PMC3837371.

Enomoto T, Kawano M, Fukuda H, Sawada W, Inoue T, Haw KC, Kita Y, Sakamoto S, Yamaguchi Y, Imai T, Hatakeyama M, Saito S, Sandhu A, Matsui M, Aoki I, Handa H. Viral protein-coating of magnetic nanoparticles using simian virus 40 VP1. J Biotechnol. 2013 Aug 10;167(1):8-15. doi: 10.1016/j.jbiotec.2013.06.005. Epub 2013 Jun 17. PubMed PMID: 23791947.

Sawada K, Horiuchi-Hirose M, Saito S, Aoki I. MRI-based morphometric characterizations of sexual dimorphism of the cerebrum of ferrets (Mustela putorius). Neuroimage. 2013 Dec;83:294-306. doi: 10.1016/j.neuroimage.2013.06.024. Epub 2013 Jun 14. PubMed PMID: 23770407.

Saito S, Hasegawa S, Sekita A, Bakalova R, Furukawa T, Murase K, Saga T, Aoki I. Manganese-enhanced MRI reveals early-phase radiation-induced cell alterations in vivo. Cancer Res. 2013 Jun 1;73(11):3216-24. doi: 10.1158/0008-5472.CAN-12-3837. Epub 2013 May 21. PubMed PMID: 23695553. (IF: 9.329)

Iida S, Imai K, Matsuda S, Itano O, Hatakeyama M, Sakamoto S, Kokuryo D, Okabayashi K, Endo T, Ishii Y, Hasegawa H, Aoki I, Handa H, Kitagawa Y. In vivo identification of sentinel lymph nodes using MRI and size-controlled and monodispersed magnetite nanoparticles. J Magn Reson Imaging. 2013 Dec;38(6):1346-55. doi: 10.1002/jmri.24108. Epub 2013 Apr 1. PubMed PMID: 23554026.

Kokuryo D, Anraku Y, Kishimura A, Tanaka S, Kano MR, Kershaw J, Nishiyama N, Saga T, Aoki I, Kataoka K. SPIO-PICsome: development of a highly sensitive and stealth-capable MRI nano-agent for tumor detection using SPIO-loaded unilamellar polyion complex vesicles (PICsomes). J Control Release. 2013 Aug 10;169(3):220-7. doi: 10.1016/j.jconrel.2013.03.016. Epub 2013 Mar 29. Erratum in: J Control Release. 2014 Mar 28;178:125. PubMed PMID: 23542239.

Bakalova R, Zhelev Z, Aoki I, Saga T. Tissue redox activity as a hallmark of carcinogenesis: from early to terminal stages of cancer. Clin Cancer Res. 2013 May 1;19(9):2503-17. doi: 10.1158/1078-0432.CCR-12-3726. Epub 2013 Mar 26. PubMed PMID: 23532887. (IF: 8.193)

Nikolova B, Kostadinova A, Dimitrov B, Zhelev Z, Bakalova R, Aoki I, Saga T, Tsoneva I. Fluorescent imaging for assessment of the effect of combined application of electroporation and rifampicin on HaCaT cells as a new therapeutic approach for psoriasis. Sensors (Basel). 2013 Mar 14;13(3):3625-34. doi: 10.3390/s130303625. PubMed PMID: 23493125; PubMed Central PMCID: PMC3658765.

Tanimoto E, Karasawan S, Ueki S, Nitta N, Aoki I, Koga N. Unexpectedly large water-proton relaxivity of TEMPO incorporated into micelle-Oligonucleotide, RSC Adv. 2013, 3: 3531–3534. DOI:10.1039/C3RA22372H.

Kershaw J, Leuze C, Aoki I, Obata T, Kanno I, Ito H, Yamaguchi Y, Handa H. Systematic changes to the apparent diffusion tensor of in vivo rat brain measured with an oscillating-gradient spin-echo sequence. Neuroimage. 2013 Apr 15;70:10-20. doi: 10.1016/j.neuroimage.2012.12.036. Epub 2012 Dec 27. PubMed PMID: 23274188.

Masamoto K, Tomita Y, Toriumi H, Aoki I, Unekawa M, Takuwa H, Itoh Y, Suzuki N, Kanno I. Repeated longitudinal in vivo imaging of neuro-glio-vascular unit at the peripheral boundary of ischemia in mouse cerebral cortex. Neuroscience. 2012 Jun 14;212:190-200. doi: 10.1016/j.neuroscience.2012.03.034. Epub 2012 Apr 16. PubMed PMID: 22516017.

Zhelev Z, Aoki I, Gadjeva V, Nikolova B, Bakalova R, Saga T. Tissue redox activity as a sensing platform for imaging of cancer based on nitroxide redox cycle. Eur J Cancer. 2013 Apr;49(6):1467-78. doi: 10.1016/j.ejca.2012.10.026. Epub 2012 Dec 20. PubMed PMID: 23265713. (IF: 5.417)

Nishimura Y, Natsume A, Ito M, Hara M, Motomura K, Fukuyama R, Sumiyoshi N, Aoki I, Saga T, Lee HJ, Wakabayashi T, Kim SU. Interferon-β delivery via human neural stem cell abates glial scar formation in spinal cord injury. Cell Transplant. 2013;22(12):2187-201. doi: 10.3727/096368912X657882. Epub 2012 Oct 12. PubMed PMID: 23068051.

Mi P, Cabral H, Kokuryo D, Rafi M, Terada Y, Aoki I, Saga T, Takehiko I, Nishiyama N, Kataoka K. Gd-DTPA-loaded polymer-metal complex micelles with high relaxivity for MR cancer imaging. Biomaterials. 2013 Jan;34(2):492-500. doi: 10.1016/j.biomaterials.2012.09.030. Epub 2012 Oct 8. PubMed PMID: 23059004.

Hadjidekov G, Hadjidekova S, Tonchev Z, Bakalova R, Aoki I. Assessing renal function in children with hydronephrosis - additional feature of MR urography. Radiol Oncol. 2011 Dec;45(4):248-58. doi: 10.2478/v10019-011-0038-z. Epub 2011 Nov 16. PubMed PMID: 22933962; PubMed Central PMCID: PMC3423747.

Jo J, Lin X, Nakahara T, Aoki I, Saga T, Tabata Y. Preparation of polymer-based magnetic resonance imaging contrast agent to visualize therapeutic angiogenesis. Tissue Eng Part A. 2013 Jan;19(1-2):30-9. doi: 10.1089/ten.TEA.2012.0131. Epub 2012 Sep 10. PubMed PMID: 22838390.

Zhelev Z, Gadjeva V, Aoki I, Bakalova R, Saga T. Cell-penetrating nitroxides as molecular sensors for imaging of cancer in vivo, based on tissue redox activity. Mol Biosyst. 2012 Oct;8(10):2733-40. doi: 10.1039/c2mb25128k. PubMed PMID: 22832934.

Sawada K, Fukunishi K, Kashima M, Saito S, Sakata-Haga H, Aoki I, Fukui Y. Fetal gyrification in cynomolgus monkeys: a concept of developmental stages of gyrification. Anat Rec (Hoboken). 2012 Jul;295(7):1065-74. doi: 10.1002/ar.22478. Epub 2012 May 17. Review. PubMed PMID: 22593081.

Toyota T, Ohguri N, Maruyama K, Fujinami M, Saga T, Aoki I. Giant vesicles containing superparamagnetic iron oxide as biodegradable cell-tracking MRI probes. Anal Chem. 2012 May 1;84(9):3952-7. doi: 10.1021/ac2031354. Epub 2012 Apr 12. PubMed PMID: 22468765.

Takanashi J, Saito S, Aoki I, Barkovich AJ, Ito Y, Inoue K. Increased N-acetylaspartate in model mouse of Pelizaeus-Merzbacher disease. J Magn Reson Imaging. 2012 Feb;35(2):418-25. PubMed PMID: 22379616.

Sawada K, Fukunishi K, Kashima M, Imai N, Saito S, Sakata-Haga H, Aoki I, Fukui Y. Neuroanatomic and magnetic resonance imaging references for normal development of cerebral sulci of laboratory primate, cynomolgus monkeys (Macaca fascicularis). Congenit Anom (Kyoto). 2012 Mar;52(1):16-27. doi: 10.1111/j.1741-4520.2011.00352.x. Review. PubMed PMID: 22348780.

Koyama T, Shimura M, Minemoto Y, Nohara S, Shibata S, Iida Y, Iwashita S, Hasegawa M, Kurabayashi T, Hamada H, Kono K, Honda E, Aoki I, Ishizaka Y. Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide. J Control Release. 2012 May 10;159(3):413-8. doi: 10.1016/j.jconrel.2012.01.023. Epub 2012 Jan 26. PubMed PMID: 22300621.

Leuze C, Kimura Y, Kershaw J, Shibata S, Saga T, Chuang KH, Shimoyama I, Aoki I. Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI (dMEMRI). Neuroimage. 2012 Mar;60(1):392-9. doi: 10.1016/j.neuroimage.2011.12.030. Epub 2011 Dec 29. PubMed PMID: 22227885.

Fukunishi K, Sawada K, Kashima M, Saito S, Sakata-Haga H, Sukamoto T, Aoki I, Fukui Y. Correlation between formation of the calcarine sulcus and morphological maturation of the lateral ventricle in cynomolgus monkey fetuses. Acta Neurobiol Exp (Wars). 2011;71(3):381-6. PubMed PMID: 22068746.

Odaka K, Aoki I, Moriya J, Tateno K, Tadokoro H, Kershaw J, Minamino T, Irie T, Fukumura T, Komuro I, Saga T. In vivo tracking of transplanted mononuclear cells using manganese-enhanced magnetic resonance imaging (MEMRI). PLoS One. 2011;6(10):e25487. doi: 10.1371/journal.pone.0025487. Epub 2011 Oct 7. PubMed PMID: 22003393; PubMed Central PMCID: PMC3189206.

Liu J, Jo J, Kawai Y, Aoki I, Tanaka C, Yamamoto M, Tabata Y. Preparation of polymer-based multimodal imaging agent to visualize the process of bone regeneration. J Control Release. 2012 Feb 10;157(3):398-405. doi: 10.1016/j.jconrel.2011.09.090. Epub 2011 Oct 1. PubMed PMID: 21982903.

Bakalova R, Zhelev Z, Kokuryo D, Spasov L, Aoki I, Saga T. Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics. Int J Nanomedicine. 2011;6:1719-32. doi: 10.2147/IJN.S17995. Epub 2011 Aug 18. PubMed PMID: 21980235; PubMed Central PMCID: PMC3184932.

Hasegawa S, Saito S, Koshikawa-Yano M, Furukawa T, Aoki I, Saga T. Tumor enhancement effect of overexpressed manganese-superoxide dismutase in manganese-enhanced MR imaging. Magn Reson Med Sci. 2011;10(3):155-8. PubMed PMID: 21959997.

Matsumura S, Aoki I, Saga T, Shiba K. A tumor-environment-responsive nanocarrier that evolves its surface properties upon sensing matrix metalloproteinase-2 and initiates agglomeration to enhance T₂ relaxivity for magnetic resonance imaging. Mol Pharm. 2011 Oct 3;8(5):1970-4. doi: 10.1021/mp2001999. Epub 2011 Sep 16. PubMed PMID: 21899281.

Autio J, Kawaguchi H, Saito S, Aoki I, Obata T, Masamoto K, Kanno I. Spatial frequency-based analysis of mean red blood cell speed in single microvessels: investigation of microvascular perfusion in rat cerebral cortex. PLoS One. 2011;6(8):e24056. doi: 10.1371/journal.pone.0024056. Epub 2011 Aug 24. PubMed PMID: 21887370; PubMed Central PMCID: PMC3161111.

Tomizawa A, Ishii I, Zhelev Z, Aoki I, Shibata S, Kitada M, Bakalova R. Carbamoyl-PROXYL-enhanced MRI detects very small disruptions in brain vascular permeability induced by dietary cholesterol. Biochim Biophys Acta. 2011 Dec;1810(12):1309-16. doi: 10.1016/j.bbagen.2011.06.011. Epub 2011 Jun 29. PubMed PMID: 21767608.

Tomizawa A, Hadjidekov G, Ishii I, Bakalova R, Zhelev Z, Aoki I, Saga T, Kitada M. Nitroxide derivatives for imaging of hypercholesterolemia-induced kidney dysfunction and assessing the effectiveness of antilipidemic drugs. Mol Pharm. 2011 Oct 3;8(5):1962-9. doi: 10.1021/mp200087v. Epub 2011 Aug 15. PubMed PMID: 21744874.

Saito S, Aoki I, Sawada K, Suhara T. Quantitative assessment of central nervous system disorder induced by prenatal X-ray exposure using diffusion and manganese-enhanced MRI. NMR Biomed. 2012 Jan;25(1):75-83. doi: 10.1002/nbm.1715. Epub 2011 Apr 28. PubMed PMID: 21538637.

Autio JA, Kershaw J, Shibata S, Obata T, Kanno I, Aoki I. High b-value diffusion-weighted fMRI in a rat forepaw electrostimulation model at 7 T. Neuroimage. 2011 Jul 1;57(1):140-8. doi: 10.1016/j.neuroimage.2011.04.006. Epub 2011 Apr 12. PubMed PMID: 21504797.

Saito S, Aoki I, Sawada K, Sun XZ, Chuang KH, Kershaw J, Kanno I, Suhara T. Quantitative and noninvasive assessment of prenatal X-ray-induced CNS abnormalities using magnetic resonance imaging. Radiat Res. 2011 Jan;175(1):1-9. doi: 10.1667/RR2134.1. Epub 2010 Nov 10. PubMed PMID: 21175341.

Jin YN, Inubushi M, Masamoto K, Odaka K, Aoki I, Tsuji AB, Sagara M, Koizumi M, Saga T. Long-term effects of hepatocyte growth factor gene therapy in rat myocardial infarct model. Gene Ther. 2012 Aug;19(8):836-43. doi:10.1038/gt.2011.128. Epub 2011 Sep 15. PubMed PMID: 21918549.

Yao R, Natsume Y, Saiki Y, Shioya H, Takeuchi K, Yamori T, Toki H, Aoki I, Saga T, Noda T. Disruption of Tacc3 function leads to in vivo tumor regression. Oncogene. 2012 Jan 12;31(2):135-48. doi: 10.1038/onc.2011.235. Epub 2011 Jun 20. PubMed PMID: 21685933.

Hasegawa S, Koshikawa-Yano M, Saito S, Morokoshi Y, Furukawa T, Aoki I, Saga T. Molecular imaging of mesothelioma by detection of manganese-superoxide dismutase activity using manganese-enhanced magnetic resonance imaging. Int J Cancer. 2011 May 1;128(9):2138-46. doi: 10.1002/ijc.25547. PubMed PMID: 20617513.

Hasegawa S, Saito S, Takanashi J, Morokoshi Y, Furukawa T, Saga T, Aoki I. Evaluation of ferritin-overexpressing brain in newly developed transgenic mice. Magn Reson Imaging. 2011 Feb;29(2):179-84. doi: 10.1016/j.mri.2010.08.013. Epub 2010 Dec 3. PubMed PMID: 21129877.

Sawada K, Sun X-Z, Fukunishi K, Kahsima M, Saito S, Aoki I, Sakata-Haga H, Fukui Y. Development of corticocortical long associative fibers in cynomolgus monkey fetal cerebrum analyzed using DTI: its relation to sulcal formation. Advanced Studies in Biology. 2011 Apr;3(3):133-150. doi:10.12988/asb. http://www.m-hikari.com/asb/asb2011/asb1-4-2011/sawadaASB1-4-2011.pdf

Kono K, Nakashima S, Kokuryo D, Aoki I, Shimomoto H, Aoshima S, Maruyama K, Yuba E, Kojima C, Harada A, Ishizaka Y. Multi-functional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy. Biomaterials. 2011 Feb;32(5):1387-95. doi: 10.1016/j.biomaterials.2010.10.050. Epub 2010 Nov 19. PubMed PMID: 21093041.

Zhelev Z, Bakalova R, Aoki I, Gadjeva V, Kanno I. Imaging of cancer by redox-mediated mechanism: a radical diagnostic approach. Mol Biosyst. 2010 Dec;6(12):2386-8. doi: 10.1039/c0mb00113a. Epub 2010 Oct 8. PubMed PMID: 20936212.

Matsumoto K, Aoki I, Nakanishi I, Matsumoto A, Nyui M, Endo K, Anzai K. Distribution of hydrogen peroxide-dependent reaction in a gelatin sample irradiated by carbon ion beam. Magn Reson Med Sci. 2010;9(3):131-40. PubMed PMID: 20885086.

Kaida S, Cabral H, Kumagai M, Kishimura A, Terada Y, Sekino M, Aoki I, Nishiyama N, Tani T, Kataoka K. Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model. Cancer Res. 2010 Sep 15;70(18):7031-41. doi: 10.1158/0008-5472.CAN-10-0303. Epub 2010 Aug 4. PubMed PMID: 20685894.

Hasegawa Y, Kinoh H, Iwadate Y, Onimaru M, Ueda Y, Harada Y, Saito S, Furuya A, Saegusa T, Morodomi Y, Hasegawa M, Saito S, Aoki I, Saeki N, Yonemitsu Y. Urokinase-targeted fusion by oncolytic Sendai virus eradicates orthotopic glioblastomas by pronounced synergy with interferon-β gene. Mol Ther. 2010 Oct;18(10):1778-86. doi: 10.1038/mt.2010.138. Epub 2010 Jul 6. PubMed PMID: 20606645; PubMed Central PMCID: PMC2951556.

Kokuryo D, Kimura Y, Obata T, Yamaya T, Kawamura K, Zhang MR, Kanno I, Aoki I. A small animal holding fixture system with positional reproducibility for longitudinal multimodal imaging. Phys Med Biol. 2010 Jul 21;55(14):4119-30. doi: 10.1088/0031-9155/55/14/011. Epub 2010 Jul 5. PubMed PMID: 20601770.

Zhelev Z, Matsumoto K, Gadjeva V, Bakalova R, Aoki I, Zheleva A, Anzai K. EPR signal reduction kinetic of several nitroxyl derivatives in blood in vitro and in vivo. Gen Physiol Biophys. 2009 Dec;28(4):356-62. PubMed PMID: 20097958.

Sawada K, Sun XZ, Fukunishi K, Kashima M, Saito S, Sakata-Haga H, Sukamoto T, Aoki I, Fukui Y. Ontogenetic pattern of gyrification in fetuses of cynomolgus monkeys. Neuroscience. 2010 May 19;167(3):735-40. doi:10.1016/j.neuroscience.2010.02.045. Epub 2010 Feb 26. PubMed PMID: 20219641.

Inoue Y, Aoki I, Mori Y, Kawai Y, Ebisu T, Osaka Y, Houri T, Mineura K, Higuchi T, Tanaka C. Detection of necrotic neural response in super-acute cerebral ischemia using activity-induced manganese-enhanced (AIM) MRI. NMR Biomed. 2010 Apr;23(3):304-12. doi: 10.1002/nbm.1464. PubMed PMID: 19950123.

Jo J, Aoki I, Tabata Y. Design of iron oxide nanoparticles with different sizes and surface charges for simple and efficient labeling of mesenchymal stem cells. J Control Release. 2010 Mar 19;142(3):465-73. doi: 10.1016/j.jconrel.2009.11.014. Epub 2009 Nov 22. PubMed PMID: 19932720.

Kawai Y, Aoki I, Umeda M, Higuchi T, Kershaw J, Higuchi M, Silva AC, Tanaka C. In vivo visualization of reactive gliosis using manganese-enhanced magnetic resonance imaging. Neuroimage. 2010 Feb 15;49(4):3122-31. doi: 10.1016/j.neuroimage.2009.11.005. Epub 2009 Nov 10. PubMed PMID: 19909819.

Zhelev Z, Bakalova R, Aoki I, Matsumoto K, Gadjeva V, Anzai K, Kanno I. Nitroxyl radicals for labeling of conventional therapeutics and noninvasive magnetic resonance imaging of their permeability for blood-brain barrier: relationship between structure, blood clearance, and MRI signal dynamic in the brain. Mol Pharm. 2009 Mar-Apr;6(2):504-12. doi: 10.1021/mp800175k. PubMed PMID: 19718801.

Matsumoto K, Nagata K, Yamamoto H, Endo K, Anzai K, Aoki I. Visualization of free radical reactions in an aqueous sample irradiated by 290 MeV carbon beam. Magn Reson Med. 2009 May;61(5):1033-9. doi: 10.1002/mrm.21958. PubMed PMID: 19253380.

Sawada K, Sun XZ, Fukunishi K, Kashima M, Sakata-Haga H, Tokado H, Aoki I, Fukui Y. Developments of sulcal pattern and subcortical structures of the forebrain in cynomolgus monkey fetuses: 7-tesla magnetic resonance imaging provides high reproducibility of gross structural changes. Brain Struct Funct. 2009 Sep;213(4-5):469-80. doi: 10.1007/s00429-009-0204-x. Epub 2009 Feb 12. PubMed PMID: 19214566.

Zhelev Z, Bakalova R, Aoki I, Matsumoto K, Gadjeva V, Anzai K, Kanno I. Nitroxyl radicals as low toxic spin-labels for non-invasive magnetic resonance imaging of blood-brain barrier permeability for conventional therapeutics. Chem Commun (Camb). 2009 Jan 7;(1):53-5. doi: 10.1039/b816878d. Epub 2008 Nov 13. PubMed PMID: 19081996.

Bakalova R, Zhelev Z, Aoki I, Masamoto K, Mileva M, Obata T, Higuchi M, Gadjeva V, Kanno I. Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects. Bioconjug Chem. 2008 Jun;19(6):1135-42. doi: 10.1021/bc700431c. Epub 2008 May 22. PubMed PMID: 18494515.

Aung W, Hasegawa S, Koshikawa-Yano M, Obata T, Ikehira H, Furukawa T, Aoki I, Saga T. Visualization of in vivo electroporation-mediated transgene expression in experimental tumors by optical and magnetic resonance imaging. Gene Ther. 2009 Jul;16(7):830-9. doi: 10.1038/gt.2009.55. Epub 2009 May 21. PubMed PMID: 19458649.

Shimizu Y, Umeda M, Mano H, Aoki I, Higuchi T, Tanaka C. Neuronal response to Shepard's tones: an auditory fMRI study using multifractal analysis. Brain Res. 2007 Dec;1186:113-23. Epub 2007 Oct 16. PubMed PMID: 17999926.

Silva AC, Lee JH, Wu CW, Tucciarone J, Pelled G, Aoki I, Koretsky AP. Detection of cortical laminar architecture using manganese-enhanced MRI. J Neurosci Methods. 2008 Jan 30;167(2):246-57. Epub 2007 Sep 2. PubMed PMID: 17936913; PubMed Central PMCID: PMC2266830.

Bakalova R, Zhelev Z, Aoki I, Kanno I. Designing quantum-dot probes. Nat Photonics, 2007, 1(9): 487-489. doi:10.1038/nphoton.2007.150.

Bakalova R, Zhelev Z, Aoki I, Ohba H, Imai Y, Kanno I. Silica-shelled single quantum dot micelles as imaging probes with dual or multimodality. Anal Chem. 2006 Aug 15;78(16):5925-32. PubMed PMID: 16906742.

Aoki I, Takahashi Y, Chuang KH, Silva AC, Igarashi T, Tanaka C, Childs RW, Koretsky AP. Cell labeling for magnetic resonance imaging with the T1 agent manganese chloride. NMR Biomed. 2006 Feb;19(1):50-9. PubMed PMID: 16411253.

Mizuguchi T, Nishimoto A, Kitsunezaki S, Yamazaki Y, Aoki I. Directional crack propagation of granular water systems. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 May;71(5 Pt 2):056122. Epub 2005 May 27. PubMed PMID: 16089617.

Aoki I, Naruse S, Tanaka C. Manganese-enhanced magnetic resonance imaging (MEMRI) of brain activity and applications to early detection of brain ischemia. NMR Biomed. 2004 Dec;17(8):569-80. Review. PubMed PMID: 15617055.

Silva AC, Lee JH, Aoki I, Koretsky AP. Manganese-enhanced magnetic resonance imaging (MEMRI): methodological and practical considerations. NMR Biomed. 2004 Dec;17(8):532-43. Review. PubMed PMID: 15617052.

Aoki I, Wu YJ, Silva AC, Lynch RM, Koretsky AP. In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI. Neuroimage. 2004 Jul;22(3):1046-59. PubMed PMID: 15219577.

Ebisu T, Mori Y, Katsuta K, Fujikawa A, Matsuoka N, Aoki I, Umeda M, Naruse S, Tanaka C. Neuroprotective effects of an immunosuppressant agent on diffusion/perfusion mismatch in transient focal ischemia. Magn Reson Med. 2004 Jun;51(6):1173-80. PubMed PMID: 15170837.

Aoki I, Ebisu T, Tanaka C, Katsuta K, Fujikawa A, Umeda M, Fukunaga M, Takegami T, Shapiro EM, Naruse S. Detection of the anoxic depolarization of focal ischemia using manganese-enhanced MRI. Magn Reson Med. 2003 Jul;50(1):7-12. PubMed PMID: 12815672.

Aoki I, Tanaka C, Takegami T, Ebisu T, Umeda M, Fukunaga M, Fukuda K, Silva AC, Koretsky AP, Naruse S. Dynamic activity-induced manganese-dependent contrast magnetic resonance imaging (DAIM MRI). Magn Reson Med. 2002 Dec;48(6):927-33. PubMed PMID: 12465100.

Ebisu T, Katsuta K, Fujikawa A, Aoki I, Umeda M, Naruse S, Tanaka C. Early and delayed neuroprotective effects of FK506 on experimental focal ischemia quantitatively assessed by diffusion-weighted MRI. Magn Reson Imaging. 2001 Feb;19(2):153-60. PubMed PMID: 11358652.

Nakamura T, Fukuda K, Hayakawa K, Aoki I, Matsumoto K, Sekine T, Ueda H, Shimizu Y. Mechanism of burn injury during magnetic resonance imaging (MRI)--simple loops can induce heat injury. Front Med Biol Eng. 2001;11(2):117-29. PubMed PMID: 11575463.

Ebisu T, Tanaka C, Umeda M, Kitamura M, Fukunaga M, Aoki I, Sato H, Higuchi T, Naruse S, Horikawa Y, Ueda S. Hemorrhagic and nonhemorrhagic stroke: diagnosis with diffusion-weighted and T2-weighted echo-planar MR imaging. Radiology. 1997 Jun;203(3):823-8. PubMed PMID: 9169711.

Iwamoto Y, Yamaki T, Murakami N, Umeda M, Tanaka C, Higuchi T, Aoki I, Naruse S, Ueda S. Investigation of morphological change of lateral and midline fluid percussion injury in rats, using magnetic resonance imaging. Neurosurgery. 1997 Jan;40(1):163-7. PubMed PMID: 8971838.

Fukunaga M, Tanaka C, Umeda M, Ebisu T, Aoki I, Watanabe Y, Higuchi T, Naruse S. Comparison of supplementary motor area activation between simple and complex motor task. Electroencephalogr Clin Neurophysiol Suppl. 1996;47:265-9. PubMed PMID: 9335991.