CV
Ichio AOKI, Ph.D.
Senior Principal Investigator
Institute for Quantum Medical Science (iQMS),
National Institutes for Quantum Science and Technology (QST)
International Society for Magnetic Resonance in Medicine: Senior Fellow
Japanese Society for Molecular Imaging (JSMI): Director
Molecular Imaging and Biology (Springer Nature): Senior Editor
RIKEN Center for Advanced Photonics: Visiting Scientist
Educational and Work Background
Educational Background
1987 Graduate from Kokura High School, Fukuoka, Japan
1993 Graduate from Faculty of Acupuncture, Meiji University of Oriental Medicine (MUOM), Kyoto, Japan
1993 Research scholar, Department of physiology, MUOM
Advisor: Kohji Fukuda, Ph.D. (NMR physics, physiology)
1994 – 1996 Master's course of medical acupuncture, Graduate school of MUOM, Japan
Thesis advisor: Chuzo Tanaka, M.D., Ph.D. (Neurosurgery, MRI in medicine) Master’s thesis entitled; "Evaluation of Rat Brain Perfusion using Arterial Spin Labeling MRI".
1996 – 1999 Doctoral course of medical acupuncture, Graduate school of MUOM, Japan
Thesis advisor: Chuzo Tanaka, M.D., PhD. Thesis entitled; "Evaluation of Brain Activation with Acupuncture Stimulation using Activity-Induced Manganese Dependent Contrast MRI in the Rat".
Work Background
1999 – 2000 Assistant Professor, Department of Physiology (Medical MR Center), MUOM, Kyoto, Japan
2000 – 2002 Visiting Fellow, Laboratory of Functional and Molecular Imaging (LFMI), National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA
2002 – 2004 Assistant Professor, Department of Medical Informatics (Medical MR Center), MUOM
2002 – 2003 Special Volunteer, LFMI, NINDS, NIH, USA
2004 – 2006 Associate Professor, Department of Medical Informatics (Medical MR Center), MUOM, Japan
2005 – 2006 Visiting Associate Scientist, Molecular Imaging Center (MIC), National Institute of Radiological Sciences (NIRS), Chiba, Japan
2006 Visiting Scientist, MIC, NIRS, Japan
2006 – 2007 Senior Principal Investigator, MIC, NIRS, Japan
2007 – 2011 Team Leader, MR Molecular Imaging Team, MIC, NIRS, Japan
2011 – 2016 Team Leader, Multimodal Molecular Imaging Team, MIC, NIRS, Japan
2016 – 2018 Group Leader, Functional and Molecular Imaging Team, NIRS, National Institutes for Quantum Science and Technology (QST), Japan
2017 – 2019 Group Leader, Group of Quantum-state Controlled MRI, QST, Japan
2018 – 2021 Group Leader, Functional and Molecular Imaging Group, NIRS, QST, Japan
2019 – 2020 Senior Group Leader, Institute for Quantum Life Science, Group of Quantum-state Controlled MRI, QST, Japan
2021 – 2023 Group leader, Functional and Molecular Imaging Group, iQMS, QST, Japan
2023 – present Senior Principal Investigator, Institute for Quantum Medical Science (iQMS), QST, Japan
Executive Board and Committee
1. Annual Meeting Program Committee (AMPC): International Society for Magnetic Resonance in Medicine (ISMRM) (2014-2017)
2. Chapter Committee: ISMRM (2019)
3. Chair (2019): Japanese Chapter, ISMRM (Vise Chair 2018, Chair 2019, Past Chair 2020)
4. Executive Board: Japanese Society for Magnetic Resonance in Medicine (2012 – 2016, 2018 – 2021)
5. Executive Board: Japanese Society for Molecular Imaging (2015 – 2019, 2021 – 2024)
6. Secretary General: Japanese Society for Molecular Imaging (2017 – 2023)
7. Council: Union of Brain Science Associations in Japan (2019 – 2020)
8. Council: The Japan Society of Drug Delivery System (2012 – 2020)
9. Review Board: Grants-in-Aid for Scientific Research (Kakenhi), The Japan Society for the Promotion of Science (JSPS) (2020 – 2022)
10. Review Board: AMED-CREST, Japan Agency for Medical Research and Development (AMED) (2023 – present)
Editorial Board:
1. Molecular Imaging and Biology (Springer, Senior editor, 2020 – 2025)
2. PLOS ONE (Academic editor, 2013 – 2021)
3. Heliyon (Academic editor, 2015 – June 2019)
4. JSMI report (Official journal of the Japanese Society for Molecular Imaging, 2010 – 2012)
Guest Lecturer/Mentor in Universities:
1. Tokyo Institute of Technology, Department of Life Science and Technology, Graduate School Lecture (2019.10.9)
2. Okayama University, Graduate School of Biomedical Sciences, Molecular Imaging Lecture (2018.12.15), Graduate School Special Lecture (2016.6.15)
3. Tokyo Medical and Dental University, Graduate School Special Lecture (2016.6.21, 2023.1.13)
4. Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (2012.6.14, 2013.6.5, 2014.6.4, 2015.5.13, 2016.6.1, 2017.5.31, 2018.5.9)
5. Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan (2013 - present)
6. Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Japan (2017.12.14)
7. Shizuoka Three Universities Cooperative Lecture (Advanced Frontier Science II) (2012.12.9)
Awards/Honors/Grants
1. Senior Fellow (2023): International Society for Magnetic Resonance in Medicine (ISMRM)
2. President’s Award of the QST 2022, “Development of Protein Nanoparticles using Quantum Beam Cross-linking Technology and their Medical Applications”
3. Mizushima Award of the Japan Society of Drug Delivery System, 2022
4. President’s Award of the QST 2019, “Establishment of Quantum Life Science”
5. President’s Award of the QST, 2017, “Manganese-enhanced MRI and the Applications”
6. The Best Presentation Award, 8th Meeting of Japanese Society for Molecular Imaging (JSMRM) 2013
7. President’s Award of the National Institute of Radiological Sciences (NIRS), 2010
8. President’s Award of 38th Annual Meeting of the Japanese Society for Magnetic Resonance in Medicine, 2010, "Quantitative manganese-enhanced MRI detects early tumor degeneration after x-ray irradiation”
9. International Jumping Award 2005 of JSMRM for the paper entitled “Methodological Issues and the Solutions for Activity-induced Manganese-dependent contrast (AIM) MRI”
10. Research Award of Meiji University of Oriental Medicine (Japan) 2005 for the paper entitled “In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI”
11. Research Award of Meiji University of Oriental Medicine (Japan) 2003 for the paper entitled “Dynamic activity-induced manganese-dependent contrast magnetic resonance imaging (DAIM MRI)”
12. Travel Stipend, 6th ISMRM, Philadelphia, Pennsylvania, 1999. “Experimental Functional MRI using Dynamic Activity-induced Manganese Dependent Contrast (DAIM)”
13. Travel Stipend, 5th ISMRM, Sydney, Australia 1998. “Limitation of Brain Perfusion Measurement by MRI in Rat Middle Cerebral Artery Occlusion Model”
1. Grant-in-Aid for Scientific Research, Kakenhi (Japan Society for the Promotion of Science; JSPS and MEXT)
2000 (challenging exploratory research): Analysis of brain metabolism of hibernant and its nerve protective effect using MRI
2002-2004 (young scientist B): Evaluation and analysis of brain functional module using activity-induced manganese depending contrast MRI.
2004-2006 (young scientist B): Visualization and evaluation of regeneration of brain functional module using activity-induced manganese depending contrast MRI.
2007-2008 (scientific research C): Development and applications of magnetic resonance cellular and molecular imaging using targeted therapeutic hybrid contrast agent.
2009-2011 (scientific research C): Development and pathological applications of functional manganese-enhanced magnetic resonance molecular imaging.
2012-2016 (scientific research B): Development and pathological applications of cell viability imaging using manganese-enhanced MRI and nano DDS.
2016-2021 (scientific research A): Development of “manganese-stained pathological analysis” using functional nano-Mn contrast agents.
2021-2025 (scientific research A): Development of "MRI Histological Analysis" by Development of Minimally Invasive Reactive Nano-manganese Contrast Agents.
2021-2026 (international collaborative research B): Pathological cell diagnosis using ultra-high field MRI through international collaborative research.
2. Selected Competitive Grants/Projects
2021-2025 MEXT/JST Advanced Research Infrastructure Sharing Promotion Project, Advanced Research Equipment Platform Program, "Research MRI Sharing Platform" (Institutional Representative)
2016-2021 AMED Strategic Promotion Program for Brain Science Research, "Development of Novel Brain Imaging by Creation of Blood-Brain Barrier-Crossing Anti-Aβ Oligomeric Antibodies" (Representative of Institution)
3. Grants for Internal Research Project
2017-2019: Quantum-state controlled MRI (QST future project)
2016-2019: Development of safer MRI contrast agents (QST president grant)
2007: Development of system for targeted-drag-release imaging and therapy using RF trigger (Institutional grant of NIRS)
2003-2005: Evaluation of brain functional module using manganese-enhanced MRI (Institutional grant of MUOM)
Patents
Registration:
1. 2022.10.11 Patent No. 7156665, "Pharmaceuticals, and methods for their production," National Institute of Quantum Science and Technology, Mitsumasa Taguchi, Akihiro Hiroki, Atsushi Kimura, Tomoko Oyama, Kengo Nakajima, Ichio Aoki, Shuhei Murayama, Yasuhiko Tabata, Junichiro Shiro, Japan, filed June 13, 2018 Patent Application 2018-113199
2. 2022.10.12 Patent No. 7157420, "Image capturing device, image capturing method, image capturing program, and storage medium," Noriaki Yawata, Ichio Aoki, Hideo Yokota, National Institute of Quantum Science and Technology and RIKEN, Japan, Filed: 2017.12.8 Patent Application 2017-. 236516. international application PCT/JP2018/045133, Patent Application 2019-558303
3. (Currently 11 registered) 2018.6.28 Patent No. 7107532 "Nanoparticles, Contrast Agents and Ligand Compounds for Magnetic Resonance Imaging Containing Nanoparticles", Daigo Miyajima, Sim Seunghyun, Takuzo Aida, Reimei Takeuchi, Ichio Aoki, National Institute of Physical and Chemical Research, National Quantum Science Technology, Japan, Patent Application 2019-526990, PCT/JP2018/24416, all PCT Contracting Parties. National transition date: December 16, 2019. jpwo2019004297a1, 2020.01.31 EU patent designation: 2021.11.9 Ukraine. 2021.11.9 Singapore registration 11201912664W. 2022.3.10 Australia registration 2018292927. 2022 .8.16 Colombia registration 40422. 2022.7.19 USA registration US11,389,550 B2. 2022.8.26 Mexico registration 395041. 2022.9.28 South Africa registration P57855ZA00/DM KISCH INC, 21:2021/04733. 2022.3. 17 Russian registration 2019143780. 2023.1.6 People's Republic of China registration ZL 2018 8 0041378. 2. 2022.3.31 Indonesia registration IDP000081634.
4. 2017-12-15 Patent No. 6256968, "Fixed Position Indication Kit and Method for Fixing Position Indication," Ichio Aoki, Junichiro Shiro, Takeo Shimomura, Daisuke Kokuryo, Tsuneo Saga, National Institute of Quantum Science and Technology, Japan, Patent Application 2013-106668.
5. 2017-3-22 Patent No. 6145612, "Polymer Nanoparticle Composite and MRI Contrast Composition Containing the Polymer Nanoparticle Composite," Kazunori Kataoka, Nobuhiro Nishiyama, Horacio Cabral, Peng Yone, Akihiro Kishimura, Yutaka Miura, Ichio Aoki, Daisuke Kokuryo, Tsuneo Saga, The University of Tokyo, National Quantum Science and Technology Agency, Japan
6. 2015-9-4 Patent No. 5802680, "Water Soluble Hyperbranch Polymers with Paramagnetic Properties," Noboru Koga, Satoru Karasawa, Xue Lei, Ichio Aoki, Sayaka Shibata, Tsuneo Saga, Osamu Hirata, Akihiro Tanaka, Osamu Uesugi, Kyushu University, Nissan Chemical Industries, Ltd, National Institute of Radiological Sciences, PCT /JP2011/77432, Application Date: 2011.11.28, Patent Application 2012-545819 (International Application)
7. 2015-02-04, 602009030414.3, Open PET-MRI machine, Taiga Yamaya, Hideo Murayama, Takayuki Obata, Ichio Aoki. registered in Germany. 2015-01-04, EP 2 407 101 B1, Open PET-MRI machine, Taiga Yamaya, Hideo Murayama, Takayuki Obata, Ichio Aoki. registered in Europe.
8. 2013.12.13, Patent No. 5429710, "Liposome containing therapeutic agent capable of tracking accumulation and release of therapeutic agent to a target site and its production method," Tatsuya Kikuchi, Ichio Aoki, Kenichi Odaka, Kenji Kono, National Institute of Radiological Sciences, Osaka Prefecture University, Japan, Application date: 2009.3.30, Patent Application 2009-082869 (maintenance abandoned)
9. 2013.11.1 Patent No. 5397976 "Polyamidoamine Dendron Lipid Containing Paramagnetic Metal", Kenji Kono and Ichio Aoki, Osaka Prefecture University and National Institute of Radiological Sciences, Japan, Application Date: 2008.4.25 Patent Application 2008-121573
10. 2013.7.19 Patent No. 5317279 "Animal Fixture" Takeo Shimomura, Ichio Aoki, Iwao Kanno, National Institute of Radiological Sciences, Japan, Application Date: 2009.5.14, Patent Application 2009-117843,
11. 2013.3.22 Patent No. 5224421 "Open PET/MRI Combination Machine," Yasuga Yamaya, Hideo Murayama, Takayuki Kobatake, and Ichio Aoki, National Institute of Radiological Sciences, Japan, Patent Application 2011-503613, Application filed May 14, 2009 (312JP) (International Application)
Patent Application:
1. 2023.7.31 "Nanoparticles formed by folding of a single polymer molecule and enhancement of modeling effect" Yutaka Miura, Nobuhiro Nishiyama, Gaoshan, Satoshi Ohno, Yoshiaki Ogata, Shodai Ishida, Ichio Aoki, Kensuke Osada, Akira Sumiyoshi. Tokyo Institute of Technology, QST, Japan, JP 2023-124868
2. 2022.4.14 "Single polymer particle, active molecule complex, method for manufacturing single polymer particle, method for measuring tumor size, method for measuring microstructure in tumor, method for imaging biological tissue, drug delivery system, contrast agent kit" Kensuke Osada, Kazuaki Rikiyama, Akira Sumiyoshi, Ichio Aoki. QST, Japan, Patent Application 2022-067148
3. 2017.9.26 "MRI contrast agent, and method for producing MRI contrast agent," Mitsumasa Taguchi, Akihiro Hiroki, Atsushi Kimura, Tomoko Oyama, Kengo Nakajima, Ichio Aoki, Shuhei Murayama, QST, Japan, Patent Application 2017-116241
4. 2016.5.2 "Method for controlling activity of bioactive substances using radiation etc., and radiation etc. stimuli-responsive gel containing bioactive substances", Shuhei Murayama, Ichio Aoki, Junichiro Shiro, Tsuneo Saga, QST, Japan, Patent Application 2016-092524
5. 2013.8.23, Macromolecule nanoparticle compound and its composition for MRI contrast agents, Kataoka K, Nishiyama N, Cabral H, Peng M, Kishimura A, Miura Y, Aoki I, Kokuryo D, Saga T. National Institute of Radiological Sciences (NIRS), Japan Patent, 2013-173866
6. 2013.5.20, Position indication kit and immobilization method, Aoki I, Shimomuta T, Kokuryo D, Saga T, NIRS, Japan Patent, 2013-106668
7. 2013.4.8, Composition of self-assemble peptide sequence and its usage, Matsumura S, Shiba K, Aoki I. NIRS, Japan Patent, 2013-80782
8. 2012.11.28, Radiation responsive hydrogel, Jo JI, Aoki I, Saga T. NIRS, Japan Patent, 2012-259393
International Press-release and Highlighted Research
1. Chemical and Engineering News (American Chemical Society), Picture-Perfect Particles Enhance MRI Signal, 2012. 4. 13, http://cen.acs.org/articles/90/web/2012/04/Picture-Perfect-Particles-Enhance-MRI.html
2. Nature Asia Materials, featured highlight: Drug development: Radical imaging, Published online 25 February 2009
3. NHK international radio, visible anticancer drug, Radio Japan Focus, broadcasting on 2009. 5. 18.
International Invited Lecture
1. Ichio Aoki, Toward the Development of Smart MRI Contrast Agents for Neuroscience and Cancer Research, Sponsored Seminar 1, International Society for Magnetic Resonance in Medicine, ISMRM JPC 2022, Nagoya Congress Center, 2022.9.10
2. Ichio Aoki, Nano-responsive and Theranostic Contrast Agents, Bruker Scientific Workshop at ISMRM 2022, London (online), 2022.5.7
3. Ichio Aoki, Overview for Manganese-enhanced MRI (MEMRI) and its Nanoparticle Applications, Member Initiated Symposium, Molecular and Cellular Imaging study group, 2020 ISMRM & SMRT Virtual Conference & Exhibition, Web, 2020.8.14
4. Ichio Aoki, Nano- and Functional-MRI Contrast Agents for Neuroscience and Cancer Research, NIH/NINDS/LFMI Seminar, Bethesda, NIH, USA, 2018.8.9
5. Ichio Aoki, Nano- and Functional-MRI Contrast Agents for Neuroscience, International Symposium on Global Neuroscience Cooperation, Kobe Convention Center, Kobe, Japan, 2018.7.29
6. Ichio Aoki, Sensing and Theranostic Contrast Agents for MRI, GI-CoRE GSQ, GSB, & IGM JOINT SYMPOSIUM: Quantum, Informatics, Biology, & Medicine, Hokkaido University, Sapporo, Japan, 2017.7.11
7. Ichio Aoki, Approach to Multiscale Imaging using Micro-MRI and Functional Contrast Agents. International Symposium on Multimodal Medical Engineering (MME), Chiba University, Japan, 2017.3.3
8. Ichio Aoki, Functional and Theranostic Contrast Agents for MRI, The l8th Northeastern Asian Symposium on Molecular Imaging-based Precision Medicine (A3 Molecular Imaging symposium), JSPS-NSFC-NRF, Eastern Cloud Hotel, Hangzhou, China. 2016.11.12
9. Ichio Aoki, Functional and theranostic contrast agents for preclinical MR imaging, Joint AMED-DFG Japan-German Workshop on Functional Metabolic Imaging, Tubingen, Germany, 2016.3.21-22
10. Ichio Aoki, Functional and theranostic MRI contrast agents, Ground Round, The university of Arizona, 2016.1.19
11. Ichio Aoki, Responsive and theranostic nano-contrast agents for preclinical MR imaging, 2014 Taiwan-Japan Symposium on Polyscale Technologies for Biomedical Engineering and Environment Science (PT-BMES 2014), Hsinchu, Taiwan, September 12-15, 2014
12. Ichio Aoki, Functional- and nano-contrast agents for preclinical MRI, The 2nd International Congress on Magnetic Resonance Imaging & the 19th Annual Scientific Meeting of KSMRM, Grand Hilton Hotel, Seoul, Korea, March 28–29, 2014
13. Ichio Aoki, Manganese enhanced MRI and drug delivery imaging, Seminar in Max Planck Institute Leipzig, Leipzig, Germany, May 10, 2010
14. Ichio Aoki, Development and theragnostic application of multimodal nano-carrier for optical and MR imaging using thermosensitive liposome, Mind/Brain International Conference, Hamamatsu, Feb 25, 2010
15. Ichio Aoki, MR-Optical Multimodal Imaging, Korean Congress of Radiology (KCR 2009), Seoul, Oct 21-23, 2009
16. Ichio Aoki, MEMRI with nanoparticle carriers and cell labeling, The 1st International Symposium for Small Animal Imaging in Korea, Korea, June 13-14, 2008
17. Ichio Aoki, Expanding applications for Manganese-enhanced MRI, International Society for Magnetic Resonance Imaging in Medicine, Molecular and Cellular Study Group Workshop, Texas, USA, 4-9 Feb 2007
18. Ichio Aoki: Manganese-enhanced MRI using High Filed Magnet, 1st Hokkaido International Crosscutting Symposium, Sapporo, July, 2006
Domestic Invited lecture
71 presentations